Hydroxychloroquine in Hospitalized Patients with COVID-19 : Real-World Experience Assessing Mortality

© 2020 Pharmacotherapy Publications, Inc..

INTRODUCTION: Hydroxychloroquine (HCQ) for coronavirus disease 2019 (COVID-19) is presently being used off-label or within a clinical trial.

OBJECTIVES: We investigated a multinational database of patients with COVID-19 with real-world data containing outcomes and their relationship to HCQ use. The primary outcome was all-cause mortality within 30 days of follow-up.

METHODS: This was a retrospective cohort study of patients receiving HCQ within 48 hours of hospital admission. Medications, preexisting conditions, clinical measures on admission, and outcomes were recorded.

RESULTS: Among patients with a diagnosis of COVID-19 in our propensity-matched cohort, the mean ages ± SD were 62.3 ± 15.9 years (53.7% male) and 61.9 ± 16.0 years (53.0% male) in the HCQ and no-HCQ groups, respectively. There was no difference in overall 30-day mortality between the HCQ and no-HCQ groups (HCQ 13.1%, n=367; no HCQ 13.6%, n=367; odds ratio 0.95, 95% confidence interval 0.62-1.46) after propensity matching. Although statistically insignificant, the HCQ-azithromycin (AZ) group had an overall mortality rate of 14.6% (n=199) compared with propensity-matched no-HCQ-AZ cohort's rate of 12.1% (n=199, OR 1.24, 95% CI 0.70-2.22). Importantly, however, there was no trend in this cohort's overall mortality/arrhythmogenesis outcome (HCQ-AZ 17.1%, no HCQ-no AZ 17.1%; OR 1.0, 95% CI 0.6-1.7).

CONCLUSIONS: We report from a large retrospective multinational database analysis of COVID-19 outcomes with HCQ and overall mortality in hospitalized patients. There was no statistically significant increase in mortality and mortality-arrhythmia with HCQ or HCQ-AZ.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:40

Enthalten in:

Pharmacotherapy - 40(2020), 11 vom: 12. Nov., Seite 1072-1081

Sprache:

Englisch

Beteiligte Personen:

Annie, Frank H [VerfasserIn]
Sirbu, Cristian [VerfasserIn]
Frazier, Keely R [VerfasserIn]
Broce, Mike [VerfasserIn]
Lucas, B Daniel [VerfasserIn]

Links:

Volltext

Themen:

4QWG6N8QKH
Antimalarial
Azithromycin
Coronavirus
Hydroxychloroquine
Journal Article
Macrolide
Research Support, N.I.H., Extramural
Severe acute respiratory syndrome coronavirus 2

Anmerkungen:

Date Completed 04.12.2020

Date Revised 12.11.2023

published: Print

Citation Status MEDLINE

doi:

10.1002/phar.2467

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM316138304