Monitoring lung impedance changes during long-term ventilator-induced lung injury ventilation using electrical impedance tomography
OBJECTIVE: The target of this methodological evaluation was the feasibility of long-term monitoring of changes in lung conditions by time-difference electrical impedance tomography (tdEIT). In contrast to ventilation monitoring by tdEIT, the monitoring of end-expiratory (EELIC) or end-inspiratory (EILIC) lung impedance change always requires a reference measurement.
APPROACH: To determine the stability of the used Pulmovista 500® EIT system, as a prerequisite it was initially secured on a resistive phantom for 50 h. By comparing the slopes of EELIC for the whole lung area up to 48 h from 36 pigs ventilated at six positive end-expiratory pressure (PEEP) levels from 0 to 18 cmH2O we found a good agreement (range of r 2 = 0.93-1.0) between absolute EIT (aEIT) and tdEIT values. This justified the usage of tdEIT with its superior local resolution compared to aEIT for long-term determination of EELIC.
MAIN RESULTS: The EELIC was between -0.07 Ωm day-1 at PEEP 4 and -1.04 Ωm day-1 at PEEP 18 cmH2O. The complex local time pattern for EELIC was roughly quantified by the new parameter, centre of end-expiratory change (CoEEC), in equivalence to the established centre of ventilation (CoV). The ventrally located mean of the CoV was fairly constant in the range of 42%-46% of thorax diameter; however, on the contrary, the CoEEC shifted from about 40% to about 75% in the dorsal direction for PEEP levels of 14 and 18 cmH2O.
SIGNIFICANCE: The observed shifts started earlier for higher PEEP levels. Changes of EELI could be precisely monitored over a period of 48 h by tdEIT on pigs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Physiological measurement - 41(2020), 9 vom: 09. Okt., Seite 095011 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hahn, G [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 23.10.2020 Date Revised 23.10.2020 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1088/1361-6579/abb1fb |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316051527 |
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| 245 | 1 | 0 | |a Monitoring lung impedance changes during long-term ventilator-induced lung injury ventilation using electrical impedance tomography |
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| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: The target of this methodological evaluation was the feasibility of long-term monitoring of changes in lung conditions by time-difference electrical impedance tomography (tdEIT). In contrast to ventilation monitoring by tdEIT, the monitoring of end-expiratory (EELIC) or end-inspiratory (EILIC) lung impedance change always requires a reference measurement | ||
| 520 | |a APPROACH: To determine the stability of the used Pulmovista 500® EIT system, as a prerequisite it was initially secured on a resistive phantom for 50 h. By comparing the slopes of EELIC for the whole lung area up to 48 h from 36 pigs ventilated at six positive end-expiratory pressure (PEEP) levels from 0 to 18 cmH2O we found a good agreement (range of r 2 = 0.93-1.0) between absolute EIT (aEIT) and tdEIT values. This justified the usage of tdEIT with its superior local resolution compared to aEIT for long-term determination of EELIC | ||
| 520 | |a MAIN RESULTS: The EELIC was between -0.07 Ωm day-1 at PEEP 4 and -1.04 Ωm day-1 at PEEP 18 cmH2O. The complex local time pattern for EELIC was roughly quantified by the new parameter, centre of end-expiratory change (CoEEC), in equivalence to the established centre of ventilation (CoV). The ventrally located mean of the CoV was fairly constant in the range of 42%-46% of thorax diameter; however, on the contrary, the CoEEC shifted from about 40% to about 75% in the dorsal direction for PEEP levels of 14 and 18 cmH2O | ||
| 520 | |a SIGNIFICANCE: The observed shifts started earlier for higher PEEP levels. Changes of EELI could be precisely monitored over a period of 48 h by tdEIT on pigs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Niewenhuys, J |e verfasserin |4 aut | |
| 700 | 1 | |a Just, A |e verfasserin |4 aut | |
| 700 | 1 | |a Tonetti, T |e verfasserin |4 aut | |
| 700 | 1 | |a Behnemann, T |e verfasserin |4 aut | |
| 700 | 1 | |a Rapetti, F |e verfasserin |4 aut | |
| 700 | 1 | |a Collino, F |e verfasserin |4 aut | |
| 700 | 1 | |a Vasques, F |e verfasserin |4 aut | |
| 700 | 1 | |a Maiolo, G |e verfasserin |4 aut | |
| 700 | 1 | |a Romitti, F |e verfasserin |4 aut | |
| 700 | 1 | |a Gattinoni, L |e verfasserin |4 aut | |
| 700 | 1 | |a Quintel, M |e verfasserin |4 aut | |
| 700 | 1 | |a Moerer, O |e verfasserin |4 aut | |
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