Adsorption of vancomycin, gentamycin, ciprofloxacin and tygecycline on the filters in continuous renal replacement therapy circuits : in full blood in vitro study
The aim of this study was to assess the in vitro adsorption of antibiotics: vancomycin, gentamicin, ciprofloxacin and tigecycline on both polyethyleneimine-treated polyacrylonitrile membrane of AN69ST filter and polysulfone membrane of AV1000 filter using porcine blood as a model close to in vivo conditions. The porcine blood with antibiotic dissolved in it was pumped into hemofiltration circuit (with AN69ST or AV1000 filter), ultrafiltration fluid was continuously returned to the reservoir containing blood with antibiotic. Blood samples to determine antibiotic concentrations were taken at minutes 0, 5, 15, 30, 45, 60, 90 and 120 from the pre- blood pump of the hemofiltration circuit. To assess possible spontaneous degradation of the drug in the solution there was an additional reservoir prepared for each antibiotic, containing blood with the drug, which was not connected to the circuit. In the case of vancomycin, ciprofloxacine and tigecycline, a statistically significant decrease in the drug concentration in the hemofiltration circuit in comparison to initial value as well as to the concentrations in the control blood was observed, both for polyacrylonitrile and plolysulfone membrane. In the case of gentamicin, significant adsorption was noted only on polyacrylonitrile membrane. Our studies demonstrated that in full blood adsorption of antibiotics may be big enough to be of clinical significance. In particular in the case of polyacrylonitrile membrane.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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Enthalten in: |
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs - 24(2021), 1 vom: 08. März, Seite 65-73 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Onichimowski, Dariusz [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 07.06.2021 Date Revised 07.06.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1007/s10047-020-01214-8 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM316039675 |
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100 | 1 | |a Onichimowski, Dariusz |e verfasserin |4 aut | |
245 | 1 | 0 | |a Adsorption of vancomycin, gentamycin, ciprofloxacin and tygecycline on the filters in continuous renal replacement therapy circuits |b in full blood in vitro study |
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520 | |a The aim of this study was to assess the in vitro adsorption of antibiotics: vancomycin, gentamicin, ciprofloxacin and tigecycline on both polyethyleneimine-treated polyacrylonitrile membrane of AN69ST filter and polysulfone membrane of AV1000 filter using porcine blood as a model close to in vivo conditions. The porcine blood with antibiotic dissolved in it was pumped into hemofiltration circuit (with AN69ST or AV1000 filter), ultrafiltration fluid was continuously returned to the reservoir containing blood with antibiotic. Blood samples to determine antibiotic concentrations were taken at minutes 0, 5, 15, 30, 45, 60, 90 and 120 from the pre- blood pump of the hemofiltration circuit. To assess possible spontaneous degradation of the drug in the solution there was an additional reservoir prepared for each antibiotic, containing blood with the drug, which was not connected to the circuit. In the case of vancomycin, ciprofloxacine and tigecycline, a statistically significant decrease in the drug concentration in the hemofiltration circuit in comparison to initial value as well as to the concentrations in the control blood was observed, both for polyacrylonitrile and plolysulfone membrane. In the case of gentamicin, significant adsorption was noted only on polyacrylonitrile membrane. Our studies demonstrated that in full blood adsorption of antibiotics may be big enough to be of clinical significance. In particular in the case of polyacrylonitrile membrane | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Adsorption | |
650 | 4 | |a Ciprofloxacin | |
650 | 4 | |a Gentamycin | |
650 | 4 | |a Tigecycline | |
650 | 4 | |a Vancomycin | |
650 | 7 | |a Acrylic Resins |2 NLM | |
650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
650 | 7 | |a Gentamicins |2 NLM | |
650 | 7 | |a Membranes, Artificial |2 NLM | |
650 | 7 | |a Polymers |2 NLM | |
650 | 7 | |a Sulfones |2 NLM | |
650 | 7 | |a polyacrylonitrile |2 NLM | |
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650 | 7 | |a polysulfone P 1700 |2 NLM | |
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650 | 7 | |a Vancomycin |2 NLM | |
650 | 7 | |a 6Q205EH1VU |2 NLM | |
650 | 7 | |a Tigecycline |2 NLM | |
650 | 7 | |a 70JE2N95KR |2 NLM | |
700 | 1 | |a Nosek, Krzysztof |e verfasserin |4 aut | |
700 | 1 | |a Ziółkowski, Hubert |e verfasserin |4 aut | |
700 | 1 | |a Jaroszewski, Jerzy |e verfasserin |4 aut | |
700 | 1 | |a Pawlos, Aleksandra |e verfasserin |4 aut | |
700 | 1 | |a Czuczwar, Mirosław |e verfasserin |4 aut | |
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