Adsorption of vancomycin, gentamycin, ciprofloxacin and tygecycline on the filters in continuous renal replacement therapy circuits : in full blood in vitro study

The aim of this study was to assess the in vitro adsorption of antibiotics: vancomycin, gentamicin, ciprofloxacin and tigecycline on both polyethyleneimine-treated polyacrylonitrile membrane of AN69ST filter and polysulfone membrane of AV1000 filter using porcine blood as a model close to in vivo conditions. The porcine blood with antibiotic dissolved in it was pumped into hemofiltration circuit (with AN69ST or AV1000 filter), ultrafiltration fluid was continuously returned to the reservoir containing blood with antibiotic. Blood samples to determine antibiotic concentrations were taken at minutes 0, 5, 15, 30, 45, 60, 90 and 120 from the pre- blood pump of the hemofiltration circuit. To assess possible spontaneous degradation of the drug in the solution there was an additional reservoir prepared for each antibiotic, containing blood with the drug, which was not connected to the circuit. In the case of vancomycin, ciprofloxacine and tigecycline, a statistically significant decrease in the drug concentration in the hemofiltration circuit in comparison to initial value as well as to the concentrations in the control blood was observed, both for polyacrylonitrile and plolysulfone membrane. In the case of gentamicin, significant adsorption was noted only on polyacrylonitrile membrane. Our studies demonstrated that in full blood adsorption of antibiotics may be big enough to be of clinical significance. In particular in the case of polyacrylonitrile membrane.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:24

Enthalten in:

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs - 24(2021), 1 vom: 08. März, Seite 65-73

Sprache:

Englisch

Beteiligte Personen:

Onichimowski, Dariusz [VerfasserIn]
Nosek, Krzysztof [VerfasserIn]
Ziółkowski, Hubert [VerfasserIn]
Jaroszewski, Jerzy [VerfasserIn]
Pawlos, Aleksandra [VerfasserIn]
Czuczwar, Mirosław [VerfasserIn]

Links:

Volltext

Themen:

25014-41-9
25135-51-7
5E8K9I0O4U
6Q205EH1VU
70JE2N95KR
Acrylic Resins
Adsorption
Anti-Bacterial Agents
Ciprofloxacin
Gentamicins
Gentamycin
Journal Article
Membranes, Artificial
Polyacrylonitrile
Polymers
Polysulfone P 1700
Sulfones
Tigecycline
Vancomycin

Anmerkungen:

Date Completed 07.06.2021

Date Revised 07.06.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s10047-020-01214-8

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM316039675