Inflammatory niche : Mesenchymal stromal cell priming by soluble mediators
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved..
Mesenchymal stromal/stem cells (MSCs) are adult stem cells of stromal origin that possess self-renewal capacity and the ability to differentiate into multiple mesodermal cell lineages. They play a critical role in tissue homeostasis and wound healing, as well as in regulating the inflammatory microenvironment through interactions with immune cells. Hence, MSCs have garnered great attention as promising candidates for tissue regeneration and cell therapy. Because the inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of MSCs, priming of MSCs with bioactive molecules has been proposed as a way to foster the therapeutic potential of these cells. In this paper, we review how soluble mediators of the inflammatory niche (cytokines and alarmins) influence the regenerative and immunomodulatory capacity of MSCs, highlighting the major advantages and concerns regarding the therapeutic potential of these inflammatory primed MSCs. The data summarized in this review may provide a significant starting point for future research on priming MSCs and establishing standardized methods for the application of preconditioned MSCs in cell therapy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
World journal of stem cells - 12(2020), 9 vom: 26. Sept., Seite 922-937 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jauković, Aleksandra [VerfasserIn] |
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| Links: |
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| Themen: |
Alarmins |
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| Anmerkungen: |
Date Revised 10.10.2020 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.4252/wjsc.v12.i9.922 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316035831 |
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| 245 | 1 | 0 | |a Inflammatory niche |b Mesenchymal stromal cell priming by soluble mediators |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. | ||
| 520 | |a Mesenchymal stromal/stem cells (MSCs) are adult stem cells of stromal origin that possess self-renewal capacity and the ability to differentiate into multiple mesodermal cell lineages. They play a critical role in tissue homeostasis and wound healing, as well as in regulating the inflammatory microenvironment through interactions with immune cells. Hence, MSCs have garnered great attention as promising candidates for tissue regeneration and cell therapy. Because the inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of MSCs, priming of MSCs with bioactive molecules has been proposed as a way to foster the therapeutic potential of these cells. In this paper, we review how soluble mediators of the inflammatory niche (cytokines and alarmins) influence the regenerative and immunomodulatory capacity of MSCs, highlighting the major advantages and concerns regarding the therapeutic potential of these inflammatory primed MSCs. The data summarized in this review may provide a significant starting point for future research on priming MSCs and establishing standardized methods for the application of preconditioned MSCs in cell therapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Alarmins | |
| 650 | 4 | |a Boosting the therapeutic potential | |
| 650 | 4 | |a Mesenchymal stem cells | |
| 650 | 4 | |a Priming | |
| 650 | 4 | |a Pro-inflammatory cytokines | |
| 700 | 1 | |a Kukolj, Tamara |e verfasserin |4 aut | |
| 700 | 1 | |a Obradović, Hristina |e verfasserin |4 aut | |
| 700 | 1 | |a Okić-Đorđević, Ivana |e verfasserin |4 aut | |
| 700 | 1 | |a Mojsilović, Slavko |e verfasserin |4 aut | |
| 700 | 1 | |a Bugarski, Diana |e verfasserin |4 aut | |
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