Clinical evaluation of an application aid for less-invasive surfactant administration (LISA)

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ..

BACKGROUND: Less-invasive surfactant administration (LISA) is increasingly used. We investigated the feasibility of a new LISA-device (Neofact®) in neonates.

DESIGN: Prospective observational pilot study with open-label LISA in two tertiary neonatal intensive care units.

PATIENTS: 20 infants with a gestational age of ≥26+0/7 weeks and an indication for LISA (Respiratory Severity Score (RSS)≥5 or fraction of inspired oxygen (FiO2) ≥0.30). Infants with respiratory tract malformations or unavailability of an instructed neonatologist were excluded.

MAIN OUTCOME MEASURES: Success of LISA, defined as laryngoscopy-confirmed intratracheal catheter position or a decrease in FiO2 by ≥0.05 or to 0.21, accompanied by an RSS decrease of ≥2; number of attempts needed for tracheal catheterisation.

RESULTS: 20/57 screened infants were enrolled. Successful application occurred in 19/20 (95%). One application failed after three attempts. No device-related adverse events occurred. The median number of attempts was 2, success rate per attempt 19/31 (61%).

CONCLUSION: LISA via Neofact® appears feasible.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:106

Enthalten in:

Archives of disease in childhood. Fetal and neonatal edition - 106(2021), 2 vom: 17. März, Seite 211-214

Sprache:

Englisch

Beteiligte Personen:

Maiwald, Christian Achim [VerfasserIn]
Neuberger, Patrick [VerfasserIn]
Franz, Axel R [VerfasserIn]
Engel, Corinna [VerfasserIn]
Vochem, Matthias [VerfasserIn]
Poets, Christian F [VerfasserIn]
Neofact – feasibility Study Group [VerfasserIn]
Neofact® – feasibility Study Group [VerfasserIn]
Arand, Jörg [Sonstige Person]
Bergmann, Iris [Sonstige Person]
Evers-Bischoff, Andrea [Sonstige Person]
Gille, Christian [Sonstige Person]
Gründler, Kerstin [Sonstige Person]
Kreutzer, Karen B [Sonstige Person]
Müller-Hansen, Ingo [Sonstige Person]
Schlunk, Christian [Sonstige Person]
Wolf, Nicole [Sonstige Person]

Links:

Volltext

Themen:

Journal Article
Neonatology
Observational Study
Pulmonary Surfactants
Resuscitation
Technology

Anmerkungen:

Date Completed 03.03.2021

Date Revised 12.03.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1136/archdischild-2020-319792

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM315940972