The Effect of Estrogen on Intracellular Ca2+ and Na+ Regulation in Heart Failure
© 2020 The Authors..
Contradictory findings of estrogen supplementation in cardiac disease highlight the need to investigate the involvement of estrogen in the progression of heart failure in an animal model that lacks traditional comorbidities. Heart failure was induced by aortic constriction (AC) in female guinea pigs. Selected AC animals were ovariectomized (ACOV), and a group of these received 17β-estradiol supplementation (ACOV+E). One hundred-fifty days post-AC surgery, left-ventricular myocytes were isolated, and their electrophysiology and Ca2+ and Na+ regulation were examined. Long-term absence of ovarian hormones exacerbates the decline in cardiac function during the progression to heart failure. Estrogen supplementation reverses these aggravating effects.
Errataetall: |
CommentIn: JACC Basic Transl Sci. 2020 Sep 28;5(9):913-915. - PMID 33016955 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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Enthalten in: |
JACC. Basic to translational science - 5(2020), 9 vom: 23. Sept., Seite 901-912 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Firth, Jahn M [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Revised 03.02.2021 published: Electronic-eCollection CommentIn: JACC Basic Transl Sci. 2020 Sep 28;5(9):913-915. - PMID 33016955 Citation Status PubMed-not-MEDLINE |
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doi: |
10.1016/j.jacbts.2020.06.013 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM315856971 |
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500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a © 2020 The Authors. | ||
520 | |a Contradictory findings of estrogen supplementation in cardiac disease highlight the need to investigate the involvement of estrogen in the progression of heart failure in an animal model that lacks traditional comorbidities. Heart failure was induced by aortic constriction (AC) in female guinea pigs. Selected AC animals were ovariectomized (ACOV), and a group of these received 17β-estradiol supplementation (ACOV+E). One hundred-fifty days post-AC surgery, left-ventricular myocytes were isolated, and their electrophysiology and Ca2+ and Na+ regulation were examined. Long-term absence of ovarian hormones exacerbates the decline in cardiac function during the progression to heart failure. Estrogen supplementation reverses these aggravating effects | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a AC, aortic constriction | |
650 | 4 | |a ACOV+E, aortic constriction with ovariectomy, supplemented with 17β-estradiol | |
650 | 4 | |a ACOV, aortic constriction with ovariectomy | |
650 | 4 | |a FS, fractional shortening | |
650 | 4 | |a ICa, l-type Ca2+ channel current (cadmium-sensitive) | |
650 | 4 | |a INa,L, late Na+ current (ranolazine-sensitive) | |
650 | 4 | |a NCX, Na+/Ca2+ exchange | |
650 | 4 | |a OV, ovariectomy | |
650 | 4 | |a SERCA, Sarco/endoplasmic reticulum Ca2+-ATPase | |
650 | 4 | |a SR, sarcoplasmic reticulum | |
650 | 4 | |a calcium regulation | |
650 | 4 | |a cardiomyocytes | |
650 | 4 | |a estrogen | |
650 | 4 | |a excitation-contraction coupling | |
650 | 4 | |a female | |
650 | 4 | |a heart failure | |
700 | 1 | |a Yang, Hsiang-Yu |e verfasserin |4 aut | |
700 | 1 | |a Francis, Alice J |e verfasserin |4 aut | |
700 | 1 | |a Islam, Najah |e verfasserin |4 aut | |
700 | 1 | |a MacLeod, Kenneth T |e verfasserin |4 aut | |
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