The Effect of Estrogen on Intracellular Ca2+ and Na+ Regulation in Heart Failure

© 2020 The Authors..

Contradictory findings of estrogen supplementation in cardiac disease highlight the need to investigate the involvement of estrogen in the progression of heart failure in an animal model that lacks traditional comorbidities. Heart failure was induced by aortic constriction (AC) in female guinea pigs. Selected AC animals were ovariectomized (ACOV), and a group of these received 17β-estradiol supplementation (ACOV+E). One hundred-fifty days post-AC surgery, left-ventricular myocytes were isolated, and their electrophysiology and Ca2+ and Na+ regulation were examined. Long-term absence of ovarian hormones exacerbates the decline in cardiac function during the progression to heart failure. Estrogen supplementation reverses these aggravating effects.

Errataetall:

CommentIn: JACC Basic Transl Sci. 2020 Sep 28;5(9):913-915. - PMID 33016955

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:5

Enthalten in:

JACC. Basic to translational science - 5(2020), 9 vom: 23. Sept., Seite 901-912

Sprache:

Englisch

Beteiligte Personen:

Firth, Jahn M [VerfasserIn]
Yang, Hsiang-Yu [VerfasserIn]
Francis, Alice J [VerfasserIn]
Islam, Najah [VerfasserIn]
MacLeod, Kenneth T [VerfasserIn]

Links:

Volltext

Themen:

AC, aortic constriction
ACOV+E, aortic constriction with ovariectomy, supplemented with 17β-estradiol
ACOV, aortic constriction with ovariectomy
Calcium regulation
Cardiomyocytes
Estrogen
Excitation-contraction coupling
FS, fractional shortening
Female
Heart failure
ICa, l-type Ca2+ channel current (cadmium-sensitive)
INa,L, late Na+ current (ranolazine-sensitive)
Journal Article
NCX, Na+/Ca2+ exchange
OV, ovariectomy
SERCA, Sarco/endoplasmic reticulum Ca2+-ATPase
SR, sarcoplasmic reticulum

Anmerkungen:

Date Revised 03.02.2021

published: Electronic-eCollection

CommentIn: JACC Basic Transl Sci. 2020 Sep 28;5(9):913-915. - PMID 33016955

Citation Status PubMed-not-MEDLINE

doi:

10.1016/j.jacbts.2020.06.013

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM315856971