Slc26a3 (DRA) in the Gut : Expression, Function, Regulation, Role in Infectious Diarrhea and Inflammatory Bowel Disease
© 2020 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
BACKGROUND: The transport of transepithelial Cl- and HCO3- is crucial for the function of the intestinal epithelium and maintains the acid-based homeostasis. Slc26a3 (DRA), as a key chloride-bicarbonate exchanger protein in the intestinal epithelial luminal membrane, participates in the electroneutral NaCl absorption of intestine, together with Na+/H+ exchangers. Increasing recent evidence supports the essential role of decreased DRA function or expression in infectious diarrhea and inflammatory bowel disease (IBD).
METHOD: In this review, we give an overview of the current knowledge of Slc26a3, including its cloning and expression, function, roles in infectious diarrhea and IBD, and mechanisms of actions. A better understanding of the physiological and pathophysiological relevance of Slc26a3 in infectious diarrhea and IBD may reveal novel targets for future therapy.
CONCLUSION: Understanding the physiological function, regulatory interactions, and the potential mechanisms of Slc26a3 in the pathophysiology of infectious diarrhea and IBD will define novel therapeutic approaches in future.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Inflammatory bowel diseases - 27(2021), 4 vom: 15. März, Seite 575-584 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yu, Qin [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 07.02.2022 Date Revised 07.02.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/ibd/izaa256 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM315601426 |
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| 500 | |a Date Revised 07.02.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: The transport of transepithelial Cl- and HCO3- is crucial for the function of the intestinal epithelium and maintains the acid-based homeostasis. Slc26a3 (DRA), as a key chloride-bicarbonate exchanger protein in the intestinal epithelial luminal membrane, participates in the electroneutral NaCl absorption of intestine, together with Na+/H+ exchangers. Increasing recent evidence supports the essential role of decreased DRA function or expression in infectious diarrhea and inflammatory bowel disease (IBD) | ||
| 520 | |a METHOD: In this review, we give an overview of the current knowledge of Slc26a3, including its cloning and expression, function, roles in infectious diarrhea and IBD, and mechanisms of actions. A better understanding of the physiological and pathophysiological relevance of Slc26a3 in infectious diarrhea and IBD may reveal novel targets for future therapy | ||
| 520 | |a CONCLUSION: Understanding the physiological function, regulatory interactions, and the potential mechanisms of Slc26a3 in the pathophysiology of infectious diarrhea and IBD will define novel therapeutic approaches in future | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a DRA | |
| 650 | 4 | |a Slc26a3 | |
| 650 | 4 | |a expression | |
| 650 | 4 | |a function | |
| 650 | 4 | |a infectious diarrhea | |
| 650 | 4 | |a inflammatory bowel disease | |
| 650 | 4 | |a regulation | |
| 650 | 7 | |a Chloride-Bicarbonate Antiporters |2 NLM | |
| 650 | 7 | |a SLC26A3 protein, human |2 NLM | |
| 650 | 7 | |a Sodium-Hydrogen Exchangers |2 NLM | |
| 650 | 7 | |a Sulfate Transporters |2 NLM | |
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