Serum ferritin level is inversely related to number of previous pregnancy losses in women with recurrent pregnancy loss
Copyright © 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved..
OBJECTIVE: To study whether low serum ferritin (s-ferritin) levels are associated with recurrent pregnancy loss (RPL), and whether low s-ferritin predicts the risk of another pregnancy loss or the ability to conceive.
DESIGN: Cohort study.
SETTING: Fertility clinic at a university hospital.
PATIENT(S): Eighty-four women referred to the RPL Unit and 153 women of reproductive age with no known fertility problem. s-Ferritin levels were measured in serum samples taken before pregnancy attempt.
INTERVENTION: None.
MAIN OUTCOME MEASURE(S): s-Ferritin levels were correlated to pregnancy history, ability to conceive, and time to conception during the first 2 years after sampling. Furthermore, s-ferritin levels were correlated to outcome of the first pregnancy after referral for RPL.
RESULT(S): Women with RPL had lower s-ferritin than the comparison group, 39.9 μg/L versus 62.2 μg/L, and had a higher prevalence of low iron stores (s-ferritin <30 μg/L), 35.7% versus 13.7%. We found an inverse relationship between s-ferritin level and number of pregnancy losses before referral. We did not find s-ferritin level to be associated with ability to conceive or time to pregnancy in either group. Nor did s-ferritin level predict the risk of losing the first pregnancy after referral for RPL.
CONCLUSION(S): The inverse relationship between s-ferritin levels and previous pregnancy losses suggests that low s-ferritin is associated with a more severe reproductive disturbance in women with RPL. Whether low s-ferritin is causally related to RPL and if such women could benefit from iron supplementation to achieve a live birth warrants further investigation.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:115 |
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Enthalten in: |
Fertility and sterility - 115(2021), 2 vom: 10. Feb., Seite 389-396 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Georgsen, Maja [VerfasserIn] |
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Links: |
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Themen: |
9007-73-2 |
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Anmerkungen: |
Date Completed 03.08.2021 Date Revised 03.08.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.fertnstert.2020.08.1410 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM315592974 |
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100 | 1 | |a Georgsen, Maja |e verfasserin |4 aut | |
245 | 1 | 0 | |a Serum ferritin level is inversely related to number of previous pregnancy losses in women with recurrent pregnancy loss |
264 | 1 | |c 2021 | |
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500 | |a Date Completed 03.08.2021 | ||
500 | |a Date Revised 03.08.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. | ||
520 | |a OBJECTIVE: To study whether low serum ferritin (s-ferritin) levels are associated with recurrent pregnancy loss (RPL), and whether low s-ferritin predicts the risk of another pregnancy loss or the ability to conceive | ||
520 | |a DESIGN: Cohort study | ||
520 | |a SETTING: Fertility clinic at a university hospital | ||
520 | |a PATIENT(S): Eighty-four women referred to the RPL Unit and 153 women of reproductive age with no known fertility problem. s-Ferritin levels were measured in serum samples taken before pregnancy attempt | ||
520 | |a INTERVENTION: None | ||
520 | |a MAIN OUTCOME MEASURE(S): s-Ferritin levels were correlated to pregnancy history, ability to conceive, and time to conception during the first 2 years after sampling. Furthermore, s-ferritin levels were correlated to outcome of the first pregnancy after referral for RPL | ||
520 | |a RESULT(S): Women with RPL had lower s-ferritin than the comparison group, 39.9 μg/L versus 62.2 μg/L, and had a higher prevalence of low iron stores (s-ferritin <30 μg/L), 35.7% versus 13.7%. We found an inverse relationship between s-ferritin level and number of pregnancy losses before referral. We did not find s-ferritin level to be associated with ability to conceive or time to pregnancy in either group. Nor did s-ferritin level predict the risk of losing the first pregnancy after referral for RPL | ||
520 | |a CONCLUSION(S): The inverse relationship between s-ferritin levels and previous pregnancy losses suggests that low s-ferritin is associated with a more severe reproductive disturbance in women with RPL. Whether low s-ferritin is causally related to RPL and if such women could benefit from iron supplementation to achieve a live birth warrants further investigation | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Recurrent pregnancy loss | |
650 | 4 | |a ferritin | |
650 | 4 | |a fertility | |
650 | 4 | |a infertility | |
650 | 4 | |a iron deficiency | |
650 | 7 | |a Biomarkers |2 NLM | |
650 | 7 | |a Ferritins |2 NLM | |
650 | 7 | |a 9007-73-2 |2 NLM | |
700 | 1 | |a Krog, Maria Christine |e verfasserin |4 aut | |
700 | 1 | |a Korsholm, Anne-Sofie |e verfasserin |4 aut | |
700 | 1 | |a Hvidman, Helene Westring |e verfasserin |4 aut | |
700 | 1 | |a Kolte, Astrid Marie |e verfasserin |4 aut | |
700 | 1 | |a Rigas, Andreas Stribolt |e verfasserin |4 aut | |
700 | 1 | |a Ullum, Henrik |e verfasserin |4 aut | |
700 | 1 | |a Ziebe, Søren |e verfasserin |4 aut | |
700 | 1 | |a Andersen, Anders Nyboe |e verfasserin |4 aut | |
700 | 1 | |a Nielsen, Henriette Svarre |e verfasserin |4 aut | |
700 | 1 | |a Hansen, Morten Bagge |e verfasserin |4 aut | |
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