The within-host viral kinetics of SARS-CoV-2
In this work, we use a within-host viral dynamic model to describe the SARS-CoV-2 kinetics in the host. Chest radiograph score data are used to estimate the parameters of that model. Our result shows that the basic reproductive number of SARS-CoV-2 in host growth is around 3.79. Using the same method we also estimate the basic reproductive number of MERS virus is 8.16 which is higher than SARS-CoV-2. The PRCC method is used to analyze the sensitivities of model parameters. Moreover, the drug effects on virus growth and immunity effect of patients are also implemented to analyze the model.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Mathematical biosciences and engineering : MBE - 17(2020), 4 vom: 26. März, Seite 2853-2861 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Chen Tong [VerfasserIn] |
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| Links: |
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| Themen: |
Basic reproductive number |
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| Anmerkungen: |
Date Completed 09.10.2020 Date Revised 18.12.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.3934/mbe.2020159 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM315581964 |
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| 245 | 1 | 4 | |a The within-host viral kinetics of SARS-CoV-2 |
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| 500 | |a Date Completed 09.10.2020 | ||
| 500 | |a Date Revised 18.12.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In this work, we use a within-host viral dynamic model to describe the SARS-CoV-2 kinetics in the host. Chest radiograph score data are used to estimate the parameters of that model. Our result shows that the basic reproductive number of SARS-CoV-2 in host growth is around 3.79. Using the same method we also estimate the basic reproductive number of MERS virus is 8.16 which is higher than SARS-CoV-2. The PRCC method is used to analyze the sensitivities of model parameters. Moreover, the drug effects on virus growth and immunity effect of patients are also implemented to analyze the model | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a MERS | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a basic reproductive number | |
| 650 | 4 | |a differential equation model | |
| 700 | 1 | |a Xu, Jin Hu |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jia Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Yi Cang |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:17 |g year:2020 |g number:4 |g day:26 |g month:03 |g pages:2853-2861 |
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