Minimum Sizes of Respiratory Particles Carrying SARS-CoV-2 and the Possibility of Aerosol Generation
This study calculates and elucidates the minimum size of respiratory particles that are potential carriers of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); furthermore, it evaluates the aerosol generation potential of SARS-CoV-2. The calculations are based on experimental results and theoretical models. In the case of maximum viral-loading derived from experimental data of COVID-19 patients, 8.97 × 10-5% of a respiratory fluid particle from a COVID-19 patient is occupied by SARS-CoV-2. Hence, the minimum size of a respiratory particle that can contain SARS-CoV-2 is calculated to be approximately 9.3 μm. The minimum size of the particles can decrease due to the evaporation of water on the particle surfaces. There are limitations to this analysis: (a) assumption that the viruses are homogeneously distributed in respiratory fluid particles and (b) considering a gene copy as a single virion in unit conversions. However, the study shows that high viral loads can decrease the minimum size of respiratory particles containing SARS-CoV-2, thereby increasing the probability of aerosol generation of the viruses. The aerosol generation theory created in this study for COVID-19 has the potential to be applied to other contagious diseases that are caused by respiratory infectious microorganisms.
Errataetall: |
ErratumIn: Int J Environ Res Public Health. 2021 Nov 09;18(22):. - PMID 34832025 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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Enthalten in: |
International journal of environmental research and public health - 17(2020), 19 vom: 23. Sept. |
Sprache: |
Englisch |
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Beteiligte Personen: |
Lee, Byung Uk [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 05.10.2020 Date Revised 17.03.2022 published: Electronic ErratumIn: Int J Environ Res Public Health. 2021 Nov 09;18(22):. - PMID 34832025 Citation Status MEDLINE |
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doi: |
10.3390/ijerph17196960 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM31548330X |
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520 | |a This study calculates and elucidates the minimum size of respiratory particles that are potential carriers of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); furthermore, it evaluates the aerosol generation potential of SARS-CoV-2. The calculations are based on experimental results and theoretical models. In the case of maximum viral-loading derived from experimental data of COVID-19 patients, 8.97 × 10-5% of a respiratory fluid particle from a COVID-19 patient is occupied by SARS-CoV-2. Hence, the minimum size of a respiratory particle that can contain SARS-CoV-2 is calculated to be approximately 9.3 μm. The minimum size of the particles can decrease due to the evaporation of water on the particle surfaces. There are limitations to this analysis: (a) assumption that the viruses are homogeneously distributed in respiratory fluid particles and (b) considering a gene copy as a single virion in unit conversions. However, the study shows that high viral loads can decrease the minimum size of respiratory particles containing SARS-CoV-2, thereby increasing the probability of aerosol generation of the viruses. The aerosol generation theory created in this study for COVID-19 has the potential to be applied to other contagious diseases that are caused by respiratory infectious microorganisms | ||
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