Controlling the Surface Functionalization of Ultrasmall Gold Nanoparticles by Sequence-Defined Macromolecules

© 2020 The Authors. Published by Wiley-VCH GmbH..

Ultrasmall gold nanoparticles (diameter about 2 nm) were surface-functionalized with cysteine-carrying precision macromolecules. These consisted of sequence-defined oligo(amidoamine)s (OAAs) with either two or six cysteine molecules for binding to the gold surface and either with or without a PEG chain (3400 Da). They were characterized by 1 H NMR spectroscopy, 1 H NMR diffusion-ordered spectroscopy (DOSY), small-angle X-ray scattering (SAXS), and high-resolution transmission electron microscopy. The number of precision macromolecules per nanoparticle was determined after fluorescent labeling by UV spectroscopy and also by quantitative 1 H NMR spectroscopy. Each nanoparticle carried between 40 and 100 OAA ligands, depending on the number of cysteine units per OAA. The footprint of each ligand was about 0.074 nm2 per cysteine molecule. OAAs are well suited to stabilize ultrasmall gold nanoparticles by selective surface conjugation and can be used to selectively cover their surface. The presence of the PEG chain considerably increased the hydrodynamic diameter of both dissolved macromolecules and macromolecule-conjugated gold nanoparticles.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:27

Enthalten in:

Chemistry (Weinheim an der Bergstrasse, Germany) - 27(2021), 4 vom: 18. Jan., Seite 1451-1464

Sprache:

Englisch

Beteiligte Personen:

van der Meer, Selina Beatrice [VerfasserIn]
Seiler, Theresa [VerfasserIn]
Buchmann, Christin [VerfasserIn]
Partalidou, Georgia [VerfasserIn]
Boden, Sophia [VerfasserIn]
Loza, Kateryna [VerfasserIn]
Heggen, Marc [VerfasserIn]
Linders, Jürgen [VerfasserIn]
Prymak, Oleg [VerfasserIn]
Oliveira, Cristiano L P [VerfasserIn]
Hartmann, Laura [VerfasserIn]
Epple, Matthias [VerfasserIn]

Links:

Volltext

Themen:

Gold
Journal Article
NMR spectroscopy
Nanoparticles
Precision macromolecules
Supramolecular chemistry

Anmerkungen:

Date Completed 19.01.2021

Date Revised 10.11.2023

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.1002/chem.202003804

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM31531138X