Prevalence and clinical relevance of tumor-associated tissue eosinophilia (TATE) in breast cancer

Copyright © 2020 Elsevier Inc. All rights reserved..

BACKGROUND: Tumor-associated tissue eosinophilia (TATE) has been associated with outcomes in a variety of solid tumors; however, its role in breast cancer is not well defined. We hypothesized that tumor-associated tissue eosinophilia is associated with a high mutation and neoantigen load, and we assessed its correlation with cancer outcomes.

METHODS: The Cancer Genome Atlas was analyzed for eosinophil signatures in breast cancer specimens. Descriptive analyses were performed, including the tumor-infiltrating cell composition using CIBERSORT, cytolytic activity score, and gene set enrichment analysis. Overall survival and disease-free survival were calculated using the Kaplan-Meier method.

RESULTS: Out of 1069 cases analyzed, 40 (3.7%) had tissue eosinophils (the tumor-associated tissue eosinophilia group). Tumor-associated tissue eosinophilia was noted in 32.5% luminal, 5% HER2-positive, and 15% triple-negative breast cancer subtypes. The single nucleotide variant-neoantigen load was significantly higher in the tumor-associated tissue eosinophilia group (P = .005), with a higher nonsilent mutation rate (P = .01). The tumor-associated tissue eosinophilia group had lower cytolytic activity (P = .02) but had enriched MYC-targeted (P = .002), E2F-targeted (P = .04), deoxyribonucleic acid repair (P = .03), and unfolded protein response gene sets (P = .05). Tumor-associated tissue eosinophilia was associated with a trend toward improved disease-free survival (P = .06) but presented no differences in overall survival (P = .56).

CONCLUSION: Tumor-associated tissue eosinophilia was noted in 3.7% of breast cancers and was associated with a higher single nucleotide variant-neoantigen load and nonsilent mutation rate, similar to that of tumor-infiltrating lymphocytes in the triple-negative subtype. However, a lower cytolytic activity score and enriched cell proliferation-related gene sets implicate different roles for tumor-associated tissue eosinophilia than for tumor-infiltrating lymphocytes.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:169

Enthalten in:

Surgery - 169(2021), 5 vom: 27. Mai, Seite 1234-1239

Sprache:

Englisch

Beteiligte Personen:

Chouliaras, Konstantinos [VerfasserIn]
Tokumaru, Yoshihisa [VerfasserIn]
Asaoka, Mariko [VerfasserIn]
Oshi, Masanori [VerfasserIn]
Attwood, Kristopher M [VerfasserIn]
Yoshida, Kazuhiro [VerfasserIn]
Ishikawa, Takashi [VerfasserIn]
Takabe, Kazuaki [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
Research Support, N.I.H., Extramural

Anmerkungen:

Date Completed 26.07.2021

Date Revised 03.05.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.surg.2020.07.052

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM315295236