Antivitamins B12 -Some Inaugural Milestones
© 2020 The Authors. Published by Wiley-VCH GmbH..
The recently delineated structure- and reactivity-based concept of antivitamins B12 has begun to bear fruit by the generation, and study, of a range of such B12 -dummies, either vitamin B12 -derived, or transition metal analogues that also represent potential antivitamins B12 or specific B12 -antimetabolites. As reviewed here, this has opened up new research avenues in organometallic B12 -chemistry and bioinorganic coordination chemistry. Exploratory studies with antivitamins B12 have, furthermore, revealed some of their potential, as pharmacologically interesting compounds, for inducing B12 -deficiency in a range of organisms, from hospital resistant bacteria to laboratory mice. The derived capacity of antivitamins B12 to induce functional B12 -deficiency in mammalian cells and organs also suggest their valuable potential as growth inhibitors of cancerous human and animal cells.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
|---|---|
| Enthalten in: |
Chemistry (Weinheim an der Bergstrasse, Germany) - 26(2020), 67 vom: 01. Dez., Seite 15438-15445 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kräutler, Bernhard [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antibiotic |
|---|
| Anmerkungen: |
Date Completed 17.02.2021 Date Revised 10.11.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1002/chem.202003788 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM315278129 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM315278129 | ||
| 003 | DE-627 | ||
| 005 | 20231225154549.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/chem.202003788 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1050.xml |
| 035 | |a (DE-627)NLM315278129 | ||
| 035 | |a (NLM)32956545 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kräutler, Bernhard |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antivitamins B12 -Some Inaugural Milestones |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 17.02.2021 | ||
| 500 | |a Date Revised 10.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The Authors. Published by Wiley-VCH GmbH. | ||
| 520 | |a The recently delineated structure- and reactivity-based concept of antivitamins B12 has begun to bear fruit by the generation, and study, of a range of such B12 -dummies, either vitamin B12 -derived, or transition metal analogues that also represent potential antivitamins B12 or specific B12 -antimetabolites. As reviewed here, this has opened up new research avenues in organometallic B12 -chemistry and bioinorganic coordination chemistry. Exploratory studies with antivitamins B12 have, furthermore, revealed some of their potential, as pharmacologically interesting compounds, for inducing B12 -deficiency in a range of organisms, from hospital resistant bacteria to laboratory mice. The derived capacity of antivitamins B12 to induce functional B12 -deficiency in mammalian cells and organs also suggest their valuable potential as growth inhibitors of cancerous human and animal cells | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a antibiotic | |
| 650 | 4 | |a cobalamin | |
| 650 | 4 | |a growth inhibitor | |
| 650 | 4 | |a transition metal | |
| 650 | 4 | |a vitamin | |
| 650 | 7 | |a Antimetabolites |2 NLM | |
| 650 | 7 | |a Vitamins |2 NLM | |
| 650 | 7 | |a Vitamin B 12 |2 NLM | |
| 650 | 7 | |a P6YC3EG204 |2 NLM | |
| 773 | 0 | 8 | |i Enthalten in |t Chemistry (Weinheim an der Bergstrasse, Germany) |d 1996 |g 26(2020), 67 vom: 01. Dez., Seite 15438-15445 |w (DE-627)NLM09455398X |x 1521-3765 |7 nnns |
| 773 | 1 | 8 | |g volume:26 |g year:2020 |g number:67 |g day:01 |g month:12 |g pages:15438-15445 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/chem.202003788 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 26 |j 2020 |e 67 |b 01 |c 12 |h 15438-15445 | ||