Firing up the cold tumors by targeting Vps34

© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC..

Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration. In our recent report published in Science Advances, we demonstrate that targeting the autophagy-related protein Vps34 switched cold immune desert tumors into hot inflamed immune-infiltrated tumors and enhanced the efficacy of anti-PD-1/PD-L1. Our study provides the preclinical rationale to set up combination immunotherapy clinical trials using selective Vps34 inhibitors and immune checkpoint blockers in melanoma and CRC.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:9

Enthalten in:

Oncoimmunology - 9(2020), 1 vom: 31. Aug., Seite 1809936

Sprache:

Englisch

Beteiligte Personen:

Janji, Bassam [VerfasserIn]
Hasmim, Meriem [VerfasserIn]
Parpal, Santiago [VerfasserIn]
Berchem, Guy [VerfasserIn]
Noman, Muhammad Zaeem [VerfasserIn]

Links:

Volltext

Themen:

Anti-PD-1/PD-L1
Autophagy
Autophagy-Related Proteins
CCL5
CXCL10
Cancer immunotherapy
Cold/hot tumors
Colon cancer
Immune landscape
Immunologic Factors
Journal Article
Melanoma
NK cells
Proinflammatory cytokines
Research Support, Non-U.S. Gov't
Review
T CD8 lymphocytes
VPS34

Anmerkungen:

Date Completed 28.07.2021

Date Revised 28.07.2021

published: Electronic

Citation Status MEDLINE

doi:

10.1080/2162402X.2020.1809936

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM315108738