Central Vestibular Tuning Arises from Patterned Convergence of Otolith Afferents

Copyright © 2020 Elsevier Inc. All rights reserved..

As sensory information moves through the brain, higher-order areas exhibit more complex tuning than lower areas. Though models predict that complexity arises via convergent inputs from neurons with diverse response properties, in most vertebrate systems, convergence has only been inferred rather than tested directly. Here, we measure sensory computations in zebrafish vestibular neurons across multiple axes in vivo. We establish that whole-cell physiological recordings reveal tuning of individual vestibular afferent inputs and their postsynaptic targets. Strong, sparse synaptic inputs can be distinguished by their amplitudes, permitting analysis of afferent convergence in vivo. An independent approach, serial-section electron microscopy, supports the inferred connectivity. We find that afferents with similar or differing preferred directions converge on central vestibular neurons, conferring more simple or complex tuning, respectively. Together, these results provide a direct, quantifiable demonstration of feedforward input convergence in vivo.

Errataetall:

ErratumIn: Neuron. 2021 Mar 3;109(5):905. - PMID 33662271

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:108

Enthalten in:

Neuron - 108(2020), 4 vom: 25. Nov., Seite 748-762.e4

Sprache:

Englisch

Beteiligte Personen:

Liu, Zhikai [VerfasserIn]
Kimura, Yukiko [VerfasserIn]
Higashijima, Shin-Ichi [VerfasserIn]
Hildebrand, David G C [VerfasserIn]
Morgan, Joshua L [VerfasserIn]
Bagnall, Martha W [VerfasserIn]

Links:

Volltext

Themen:

Body balance
Electrical synapse
Feedforward excitation
High-pass tuning
Journal Article
Neural computation
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Sensorimotor transformation
Sensory encoding
Vestibulospinal neuron

Anmerkungen:

Date Completed 22.01.2021

Date Revised 26.11.2021

published: Print-Electronic

ErratumIn: Neuron. 2021 Mar 3;109(5):905. - PMID 33662271

Citation Status MEDLINE

doi:

10.1016/j.neuron.2020.08.019

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM315089261