Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging
Killing tumor cells with a visualized system is a promising strategy in tumor therapy to achieve minimal side effects and high efficiency. Herein, a theranostic nanomedicine (AuNCs-Pt) is developed based on nanocarrier gold nanoclusters (AuNCs) with bifunctions of both NIR-I/NIR-II imaging and glutathione-scavenging abilities. AuNCs-Pt possesses NIR-II imaging capability on a fatal high-grade serous ovarian cancer (HGSOC) model in the deep abdomen, thus facilitating it to be a promising tool for monitoring platinum transportation. Meanwhile, AuNCs-Pt depletes intracellular glutathione to minimize platinum detoxification, effectively maximizing the chemotherapeutic efficacy of platinum. AuNCs-Pt is used to eradicate the tumor burden in this study on a HGSOC model and a patient-derived tumor xenograft model of hepatocellular carcinoma, suggesting great potential for clinical visualized therapy and platinum drug sensitization.
| Errataetall: |
ErratumIn: ACS Nano. 2022 Jun 28;16(6):9960. - PMID 35605181 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
ACS nano - 14(2020), 10 vom: 27. Okt., Seite 13536-13547 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yang, Yuanyuan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.05.2021 Date Revised 23.05.2022 published: Print-Electronic ErratumIn: ACS Nano. 2022 Jun 28;16(6):9960. - PMID 35605181 Citation Status MEDLINE |
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| doi: |
10.1021/acsnano.0c05541 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314965750 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Killing tumor cells with a visualized system is a promising strategy in tumor therapy to achieve minimal side effects and high efficiency. Herein, a theranostic nanomedicine (AuNCs-Pt) is developed based on nanocarrier gold nanoclusters (AuNCs) with bifunctions of both NIR-I/NIR-II imaging and glutathione-scavenging abilities. AuNCs-Pt possesses NIR-II imaging capability on a fatal high-grade serous ovarian cancer (HGSOC) model in the deep abdomen, thus facilitating it to be a promising tool for monitoring platinum transportation. Meanwhile, AuNCs-Pt depletes intracellular glutathione to minimize platinum detoxification, effectively maximizing the chemotherapeutic efficacy of platinum. AuNCs-Pt is used to eradicate the tumor burden in this study on a HGSOC model and a patient-derived tumor xenograft model of hepatocellular carcinoma, suggesting great potential for clinical visualized therapy and platinum drug sensitization | ||
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| 700 | 1 | |a Chen, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Meng, Xiangxi |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Wen |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ziyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Changhui |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Haile |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiaodong |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Haihua |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Zhiqiang |e verfasserin |4 aut | |
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