Hydroxy-corrole and its gallium(III) complex as new photosensitizer for photodynamic therapy against breast carcinoma
Copyright © 2020 Elsevier Masson SAS. All rights reserved..
Three mono-hydroxy corroles 1-3 and their gallium(III) complexes Ga1-3 were synthesized, and their photodynamic antitumour activities towards breast cancer cells were investigated. All corroles showed excellent cytotoxicity against the MDA-MB-231 and 4T1 cell lines upon light irradiation at 625 nm. Ga3 exhibited excellent phototoxicity and selectivity against MDA-MB-231 cells, with an IC50 of 0.06 ± 0.03 μM and a selective index value of 1338.83 (relative to human normal Huvec cells). The performance of Ga3 was even better than that of the clinical photodynamic therapy drug m-THPC. A preliminary mechanistic investigation revealed that corrole 3 and Ga3 were mainly located in the cytoplasm. Upon irradiation, they could generate intracellular reactive oxygen to destroy the mitochondrial membrane potential and arrest the cell cycle at the sub-G1 phase. Flow cytometry revealed that corrole 3 and Ga3 induced cancer cell apoptosis after photodynamic treatment. Corrole 3 and Ga3 displayed negligible cytotoxicity in the dark. These results suggest that corrole 3 and Ga3 are promising candidates for use in the photodynamic therapy of breast cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:208 |
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| Enthalten in: |
European journal of medicinal chemistry - 208(2020) vom: 15. Dez., Seite 112794 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sun, Yan-Mei [VerfasserIn] |
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| Links: |
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| Themen: |
Breast carcinoma |
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| Anmerkungen: |
Date Completed 26.05.2021 Date Revised 26.05.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejmech.2020.112794 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31488484X |
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| 245 | 1 | 0 | |a Hydroxy-corrole and its gallium(III) complex as new photosensitizer for photodynamic therapy against breast carcinoma |
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| 500 | |a Date Revised 26.05.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a Three mono-hydroxy corroles 1-3 and their gallium(III) complexes Ga1-3 were synthesized, and their photodynamic antitumour activities towards breast cancer cells were investigated. All corroles showed excellent cytotoxicity against the MDA-MB-231 and 4T1 cell lines upon light irradiation at 625 nm. Ga3 exhibited excellent phototoxicity and selectivity against MDA-MB-231 cells, with an IC50 of 0.06 ± 0.03 μM and a selective index value of 1338.83 (relative to human normal Huvec cells). The performance of Ga3 was even better than that of the clinical photodynamic therapy drug m-THPC. A preliminary mechanistic investigation revealed that corrole 3 and Ga3 were mainly located in the cytoplasm. Upon irradiation, they could generate intracellular reactive oxygen to destroy the mitochondrial membrane potential and arrest the cell cycle at the sub-G1 phase. Flow cytometry revealed that corrole 3 and Ga3 induced cancer cell apoptosis after photodynamic treatment. Corrole 3 and Ga3 displayed negligible cytotoxicity in the dark. These results suggest that corrole 3 and Ga3 are promising candidates for use in the photodynamic therapy of breast cancer | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Breast carcinoma | |
| 650 | 4 | |a Corrole | |
| 650 | 4 | |a Gallium(III) complex | |
| 650 | 4 | |a Photodynamic therapy | |
| 650 | 4 | |a Photosensitizer | |
| 650 | 7 | |a Coordination Complexes |2 NLM | |
| 650 | 7 | |a Photosensitizing Agents |2 NLM | |
| 650 | 7 | |a Porphyrins |2 NLM | |
| 650 | 7 | |a Reactive Oxygen Species |2 NLM | |
| 650 | 7 | |a Gallium |2 NLM | |
| 650 | 7 | |a CH46OC8YV4 |2 NLM | |
| 700 | 1 | |a Jiang, Xiao |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ze-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ling-Gui |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Yu-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Hai-Yang |e verfasserin |4 aut | |
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