Prognostic value of pretreatment MRI texture features in breast cancer brain metastasis treated with Gamma Knife radiosurgery
BACKGROUND: Gamma Knife radiosurgery (GKS) was recommended for treating patients with breast cancer brain metastasis (BCBM), but predictions of the existing prognostic models for therapeutic responsiveness vary substantially.
PURPOSE: To investigate the prognostic value of pretreatment clinical, MRI radiologic, and texture features in patients with BCBM undergoing GKS.
MATERIAL AND METHODS: The data of 81 BCBMs in 44 patients were retrospectively reviewed. Progressive disease was defined as an increase of at least 20% in the longest diameter of the target lesion or the presence of new intracranial lesions on contrast-enhanced T1-weighted (CE-T1W) imaging. Radiomic features were extracted from pretreatment CE-T1W images, T2-weighted (T2W) images, and ADC maps. Cox proportional hazard analyses were performed to identify independent predictors associated with BCBM-specific progression-free survival (PFS). A nomogram was constructed and its calibration ability was assessed.
RESULTS: The cumulative BCBM-specific PFS was 52.27% at six months and 11.36% at one year, respectively. Age (hazard ratio [HR] 1.04; 95% confidence interval [CI] 1.01-1.06; P = 0.004) and CE-T1W-based kurtosis (HR 0.72; 95% CI 0.57-0.92; P = 0.008) were the independent predictors. The combination of CE-T1W-based kurtosis and age displayed a higher C-index (C-index 0.70; 95% CI 0.63-0.77) than did CE-T1W-based kurtosis (C-index 0.65; 95% CI 0.57-0.73) or age (C-index 0.63; 95% CI 0.56-0.70) alone. The nomogram based on the combinative model provided a better performance over age (P < 0.05). The calibration curves elucidated good agreement between prediction and observation for the probability of 7- and 12-month BCBM-specific PFS.
CONCLUSION: Pretreatment CE-T1W-based kurtosis combined with age could improve prognostic ability in patients with BCBM undergoing GKS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
Acta radiologica (Stockholm, Sweden : 1987) - 62(2021), 9 vom: 18. Sept., Seite 1208-1216 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zheng, Yingyan [VerfasserIn] |
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| Links: |
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| Themen: |
Contrast Media |
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| Anmerkungen: |
Date Completed 08.09.2021 Date Revised 08.09.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/0284185120956296 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314828958 |
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| 041 | |a eng | ||
| 100 | 1 | |a Zheng, Yingyan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic value of pretreatment MRI texture features in breast cancer brain metastasis treated with Gamma Knife radiosurgery |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Revised 08.09.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Gamma Knife radiosurgery (GKS) was recommended for treating patients with breast cancer brain metastasis (BCBM), but predictions of the existing prognostic models for therapeutic responsiveness vary substantially | ||
| 520 | |a PURPOSE: To investigate the prognostic value of pretreatment clinical, MRI radiologic, and texture features in patients with BCBM undergoing GKS | ||
| 520 | |a MATERIAL AND METHODS: The data of 81 BCBMs in 44 patients were retrospectively reviewed. Progressive disease was defined as an increase of at least 20% in the longest diameter of the target lesion or the presence of new intracranial lesions on contrast-enhanced T1-weighted (CE-T1W) imaging. Radiomic features were extracted from pretreatment CE-T1W images, T2-weighted (T2W) images, and ADC maps. Cox proportional hazard analyses were performed to identify independent predictors associated with BCBM-specific progression-free survival (PFS). A nomogram was constructed and its calibration ability was assessed | ||
| 520 | |a RESULTS: The cumulative BCBM-specific PFS was 52.27% at six months and 11.36% at one year, respectively. Age (hazard ratio [HR] 1.04; 95% confidence interval [CI] 1.01-1.06; P = 0.004) and CE-T1W-based kurtosis (HR 0.72; 95% CI 0.57-0.92; P = 0.008) were the independent predictors. The combination of CE-T1W-based kurtosis and age displayed a higher C-index (C-index 0.70; 95% CI 0.63-0.77) than did CE-T1W-based kurtosis (C-index 0.65; 95% CI 0.57-0.73) or age (C-index 0.63; 95% CI 0.56-0.70) alone. The nomogram based on the combinative model provided a better performance over age (P < 0.05). The calibration curves elucidated good agreement between prediction and observation for the probability of 7- and 12-month BCBM-specific PFS | ||
| 520 | |a CONCLUSION: Pretreatment CE-T1W-based kurtosis combined with age could improve prognostic ability in patients with BCBM undergoing GKS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Gamma Knife radiosurgery | |
| 650 | 4 | |a Metastases | |
| 650 | 4 | |a nomogram | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a radiomics | |
| 650 | 7 | |a Contrast Media |2 NLM | |
| 700 | 1 | |a Geng, Daoying |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Tonggang |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a She, Dejun |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Bo |e verfasserin |4 aut | |
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