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Advances in Topical Hemostatic Agent Therapies : A Comprehensive Update

Severe hemorrhage causes significant metabolic and cellular dysfunction secondary to deficient tissue perfusion and oxygen delivery. If bleeding continues, hemodynamic destabilization, hypoxemia, multiple organ failure, and death will occur. Techniques employed to promote hemostasis include surgical suture ligatures, cautery, chemical agents, self-assembling nanoparticles, and physical methods, like mechanical pressure. Improved understanding of the natural clotting cascade has allowed newly designed agents to become more targeted for clinical and military use. Topically-applied hemostatic agents have enormous clinical applications in achieving hemostasis. This manuscript describes currently available and developing topical hemostatic materials, including topical active agents, mechanical agents, synthetic/hemisynthetic hemostatic agents, and external hemostatic dressings for clinical practice

Year of Publication: 2020
Contained in: Advances in therapy Vol. 37, No. 10 (2020), p. 4132-4148
All journal articles: Search for all articles in this journal
Language: English
Contributors: Huang, Liang | Author
Liu, Geoffrey L
Kaye, Alan D
Liu, Henry
Full text access:
Electronic availability is being checked...
Links: Full Text (dx.doi.org)
Keywords: Adhesive
Fibrin
Gelatin
Hemostatic dressings
Hemostats
Journal Article
Review
Sealant
Thrombin
Topical agent
ISSN: 1865-8652
Note: Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Notes: Date Revised 16.09.2020
published: Print-Electronic
Citation Status In-Data-Review
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PMID:
    32813165
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.1007/s12325-020-01467-y
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