Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development
Presynaptic spike timing-dependent long-term depression (t-LTD) at hippocampal CA3-CA1 synapses is evident until the 3rd postnatal week in mice, disappearing during the 4th week. At more mature stages, we found that the protocol that induced t-LTD induced t-LTP. We characterized this form of t-LTP and the mechanisms involved in its induction, as well as that driving this switch from t-LTD to t-LTP. We found that this t-LTP is expressed presynaptically at CA3-CA1 synapses, as witnessed by coefficient of variation, number of failures, paired-pulse ratio and miniature responses analysis. Additionally, this form of presynaptic t-LTP does not require NMDARs but the activation of mGluRs and the entry of Ca2+ into the postsynaptic neuron through L-type voltage-dependent Ca2+ channels and the release of Ca2+ from intracellular stores. Nitric oxide is also required as a messenger from the postsynaptic neuron. Crucially, the release of adenosine and glutamate by astrocytes is required for t-LTP induction and for the switch from t-LTD to t-LTP. Thus, we have discovered a developmental switch of synaptic transmission from t-LTD to t-LTP at hippocampal CA3-CA1 synapses in which astrocytes play a central role and revealed a form of presynaptic LTP and the rules for its induction.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Nature communications - 11(2020), 1 vom: 01. Sept., Seite 4388 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Falcón-Moya, Rafael [VerfasserIn] |
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| Links: |
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| Themen: |
3KX376GY7L |
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| Anmerkungen: |
Date Completed 21.09.2020 Date Revised 22.04.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41467-020-18024-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314467920 |
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| 100 | 1 | |a Falcón-Moya, Rafael |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development |
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| 520 | |a Presynaptic spike timing-dependent long-term depression (t-LTD) at hippocampal CA3-CA1 synapses is evident until the 3rd postnatal week in mice, disappearing during the 4th week. At more mature stages, we found that the protocol that induced t-LTD induced t-LTP. We characterized this form of t-LTP and the mechanisms involved in its induction, as well as that driving this switch from t-LTD to t-LTP. We found that this t-LTP is expressed presynaptically at CA3-CA1 synapses, as witnessed by coefficient of variation, number of failures, paired-pulse ratio and miniature responses analysis. Additionally, this form of presynaptic t-LTP does not require NMDARs but the activation of mGluRs and the entry of Ca2+ into the postsynaptic neuron through L-type voltage-dependent Ca2+ channels and the release of Ca2+ from intracellular stores. Nitric oxide is also required as a messenger from the postsynaptic neuron. Crucially, the release of adenosine and glutamate by astrocytes is required for t-LTP induction and for the switch from t-LTD to t-LTP. Thus, we have discovered a developmental switch of synaptic transmission from t-LTD to t-LTP at hippocampal CA3-CA1 synapses in which astrocytes play a central role and revealed a form of presynaptic LTP and the rules for its induction | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Receptors, Metabotropic Glutamate |2 NLM | |
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| 700 | 1 | |a Pérez-Rodríguez, Mikel |e verfasserin |4 aut | |
| 700 | 1 | |a Prius-Mengual, José |e verfasserin |4 aut | |
| 700 | 1 | |a Andrade-Talavera, Yuniesky |e verfasserin |4 aut | |
| 700 | 1 | |a Arroyo-García, Luis E |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Artés, Rocío |e verfasserin |4 aut | |
| 700 | 1 | |a Mateos-Aparicio, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Guerra-Gomes, Sónia |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira, João Filipe |e verfasserin |4 aut | |
| 700 | 1 | |a Flores, Gonzalo |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Moreno, Antonio |e verfasserin |4 aut | |
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