Gestational Diabetes Type 2 : Variation in High-Density Lipoproteins Composition and Function
Aims: Class A2 gestational diabetes mellitus (GDMA2) has short- and long-term effects on the mother and child. These may include abnormalities of placentation, damage to endothelial cells and cardiovascular disease. This research investigated the function and composition of high-density lipoproteins (HDL) among women with GDMA2 and their fetuses. Methods: Thirty pregnant women were recruited during admission for delivery. The function and expression of HDL, paraoxonase1 (PON1) and apolipoprotein A1 (APOA1) in the blood samples and the placental tissue were evaluated. The effect of HDL on migration of endothelial cells was measured in vitro. Results: Compared to normal pregnancy (NP), APOA1 in the maternal plasma of women with GDMA2 was decreased. More APOA1 and PON1 were released from HDL of women with GDMA2, compared to NP. Placental APOA1 and PON1 were decreased in GDMA2. For endothelial cells stimulated with TNFα, HDL cell migration was decreased when cells were evaluated with NP-HDL, as compared to GDMA2-HDL. Conclusions: GDMA2 affects the composition and function of HDL in plasma. Changes in HDL commonly seen in GDMA2 were observed in maternal and placental samples, but not in cord samples. These results might indicate a placental role in protecting the fetus by preserving the components and functions of HDL and require further investigation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
International journal of molecular sciences - 21(2020), 17 vom: 30. Aug. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pasternak, Yael [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 17.02.2021 Date Revised 17.02.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/ijms21176281 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314456600 |
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| 100 | 1 | |a Pasternak, Yael |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Gestational Diabetes Type 2 |b Variation in High-Density Lipoproteins Composition and Function |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 17.02.2021 | ||
| 500 | |a Date Revised 17.02.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aims: Class A2 gestational diabetes mellitus (GDMA2) has short- and long-term effects on the mother and child. These may include abnormalities of placentation, damage to endothelial cells and cardiovascular disease. This research investigated the function and composition of high-density lipoproteins (HDL) among women with GDMA2 and their fetuses. Methods: Thirty pregnant women were recruited during admission for delivery. The function and expression of HDL, paraoxonase1 (PON1) and apolipoprotein A1 (APOA1) in the blood samples and the placental tissue were evaluated. The effect of HDL on migration of endothelial cells was measured in vitro. Results: Compared to normal pregnancy (NP), APOA1 in the maternal plasma of women with GDMA2 was decreased. More APOA1 and PON1 were released from HDL of women with GDMA2, compared to NP. Placental APOA1 and PON1 were decreased in GDMA2. For endothelial cells stimulated with TNFα, HDL cell migration was decreased when cells were evaluated with NP-HDL, as compared to GDMA2-HDL. Conclusions: GDMA2 affects the composition and function of HDL in plasma. Changes in HDL commonly seen in GDMA2 were observed in maternal and placental samples, but not in cord samples. These results might indicate a placental role in protecting the fetus by preserving the components and functions of HDL and require further investigation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a APOA1 | |
| 650 | 4 | |a GDMA2 | |
| 650 | 4 | |a HDL | |
| 650 | 4 | |a HUVEC | |
| 650 | 4 | |a PON1 | |
| 650 | 4 | |a placenta | |
| 650 | 7 | |a APOA1 protein, human |2 NLM | |
| 650 | 7 | |a Apolipoprotein A-I |2 NLM | |
| 650 | 7 | |a Lipoproteins, HDL |2 NLM | |
| 650 | 7 | |a TNF protein, human |2 NLM | |
| 650 | 7 | |a Tumor Necrosis Factor-alpha |2 NLM | |
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| 700 | 1 | |a Ohana, Meital |e verfasserin |4 aut | |
| 700 | 1 | |a Einbinder, Yael |e verfasserin |4 aut | |
| 700 | 1 | |a Arbib, Nissim |e verfasserin |4 aut | |
| 700 | 1 | |a Benchetrit, Sydney |e verfasserin |4 aut | |
| 700 | 1 | |a Zitman-Gal, Tali |e verfasserin |4 aut | |
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