Bleeding Disorders in Bothrops atrox Envenomations in the Brazilian Amazon : Participation of Hemostatic Factors and the Impact of Tissue Factor
Bleeding is a common hemostatic disorder that occurs in Bothrops envenomations. We evaluated the changes in coagulation, fibrinolysis components, and platelets in Bothrops atrox envenomations with bleeding. This is an observational study with B. atrox snakebite patients (n = 100) treated in Manaus, Brazilian Amazon. Bleeding was recorded on admission and during hospitalization. We found that the platelet count in our patients presented a weak correlation to tissue factor, factor II, and plasminogen. Tissue factor presented weak correlation to factor V, II, D-dimer, plasminogen, alpha 2-antiplasmin, and moderate correlation to fibrinogen and fibrin/fibrinogen degradation product (FDP). Patients with systemic bleeding (n = 20) presented low levels of factor V, II, fibrinogen, plasminogen, and alpha 2-antiplasmin, and high levels of tissue factor and FDP compared to those without bleeding. Patients with only local bleeding (n = 41) and without bleeding showed similar levels of hemostatic factors. Thrombocytopenia was observed mainly in patients with systemic bleeding and increased levels of serum venom. No association was found between venom levels and systemic bleeding, or between venom levels and clinical severity of envenomation. This is the first report that shows the participation of the extrinsic coagulation pathway in the consumption coagulopathy of B. atrox envenomations with systemic bleeding due to tissue factor release.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Toxins - 12(2020), 9 vom: 29. Aug. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
S Oliveira, Sâmella [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 17.06.2021 Date Revised 17.06.2021 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.3390/toxins12090554 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM314454012 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM314454012 | ||
| 003 | DE-627 | ||
| 005 | 20231225152753.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/toxins12090554 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1048.xml |
| 035 | |a (DE-627)NLM314454012 | ||
| 035 | |a (NLM)32872404 | ||
| 035 | |a (PII)E554 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a S Oliveira, Sâmella |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Bleeding Disorders in Bothrops atrox Envenomations in the Brazilian Amazon |b Participation of Hemostatic Factors and the Impact of Tissue Factor |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 17.06.2021 | ||
| 500 | |a Date Revised 17.06.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Bleeding is a common hemostatic disorder that occurs in Bothrops envenomations. We evaluated the changes in coagulation, fibrinolysis components, and platelets in Bothrops atrox envenomations with bleeding. This is an observational study with B. atrox snakebite patients (n = 100) treated in Manaus, Brazilian Amazon. Bleeding was recorded on admission and during hospitalization. We found that the platelet count in our patients presented a weak correlation to tissue factor, factor II, and plasminogen. Tissue factor presented weak correlation to factor V, II, D-dimer, plasminogen, alpha 2-antiplasmin, and moderate correlation to fibrinogen and fibrin/fibrinogen degradation product (FDP). Patients with systemic bleeding (n = 20) presented low levels of factor V, II, fibrinogen, plasminogen, and alpha 2-antiplasmin, and high levels of tissue factor and FDP compared to those without bleeding. Patients with only local bleeding (n = 41) and without bleeding showed similar levels of hemostatic factors. Thrombocytopenia was observed mainly in patients with systemic bleeding and increased levels of serum venom. No association was found between venom levels and systemic bleeding, or between venom levels and clinical severity of envenomation. This is the first report that shows the participation of the extrinsic coagulation pathway in the consumption coagulopathy of B. atrox envenomations with systemic bleeding due to tissue factor release | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Bothrops atrox envenomation | |
| 650 | 4 | |a coagulation factors | |
| 650 | 4 | |a systemic bleeding | |
| 650 | 4 | |a thrombocytopenia | |
| 650 | 4 | |a tissue factor | |
| 650 | 7 | |a Antivenins |2 NLM | |
| 650 | 7 | |a Blood Coagulation Factors |2 NLM | |
| 650 | 7 | |a Crotalid Venoms |2 NLM | |
| 650 | 7 | |a Thromboplastin |2 NLM | |
| 650 | 7 | |a 9035-58-9 |2 NLM | |
| 700 | 1 | |a C Alves, Eliane |e verfasserin |4 aut | |
| 700 | 1 | |a S Santos, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a F Nascimento, Elizandra |e verfasserin |4 aut | |
| 700 | 1 | |a T Pereira, João Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a M Silva, Iran |e verfasserin |4 aut | |
| 700 | 1 | |a A G Sachett, Jacqueline |e verfasserin |4 aut | |
| 700 | 1 | |a S Sarraff, Lybia Kássia |e verfasserin |4 aut | |
| 700 | 1 | |a Freitas-de-Sousa, Luciana Aparecida |e verfasserin |4 aut | |
| 700 | 1 | |a Colombini, Mônica |e verfasserin |4 aut | |
| 700 | 1 | |a O Marques, Hedylamar |e verfasserin |4 aut | |
| 700 | 1 | |a V G Lacerda, Marcus |e verfasserin |4 aut | |
| 700 | 1 | |a Sartim, Marco Aurélio |e verfasserin |4 aut | |
| 700 | 1 | |a Moura-da-Silva, Ana Maria |e verfasserin |4 aut | |
| 700 | 1 | |a L Ferreira, Luiz Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a S Sano-Martins, Ida |e verfasserin |4 aut | |
| 700 | 1 | |a M Monteiro, Wuelton |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Toxins |d 2009 |g 12(2020), 9 vom: 29. Aug. |w (DE-627)NLM199735913 |x 2072-6651 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2020 |g number:9 |g day:29 |g month:08 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/toxins12090554 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2020 |e 9 |b 29 |c 08 | ||