Comparison of different criteria for the definition of insulin resistance and its relationship to metabolic risk in children and adolescents

PURPOSE: Childhood obesity frequently persists into adulthood and is associated with insulin resistance (IR) and increased long-term morbidity and mortality. We compared IR criteria concerning 'age-specific cutoff point' (ACOP) and 'fixed cutoff point' (FCOP) for the identification of IR and investigated their correlation with metabolic syndrome (MS).

METHODS: Data were acquired from the 5th Korea National Health and Nutrition Examination Survey (2010-2011). Participants ranged from 10 to 17 years of age and underwent fasting plasma glucose, insulin concentration, and lipid panel measurements. High fasting plasma insulin levels or increased homeostatic model assessment insulin resistance (HOMA-IR) were defined as IR. We analyzed MS and IR frequencies according to FCOP or ACOP.

RESULTS: Among 719 participants, 165 (22.9%) were overweight or obese based on their body mass index. We found no prevalence of MS in underweight/normal weight participants and 12.7% prevalence rate in overweight or obese participants. IR according to ACOP was more closely associated with MS than IR according to FCOP. No differences were found in predicting the frequency of MS using FCOP or ACOP in both fasting plasma insulin and HOMA-IR.

CONCLUSION: The frequency of MS in participants with IR defined using ACOP and FCOP was similar. However, IR using ACOP was more closely associated with MS than IR using FCOP.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:25

Enthalten in:

Annals of pediatric endocrinology & metabolism - 25(2020), 4 vom: 20. Dez., Seite 227-233

Sprache:

Englisch

Beteiligte Personen:

Lee, Seon Hwa [VerfasserIn]
Ahn, Moon Bae [VerfasserIn]
Choi, Yu Jung [VerfasserIn]
Kim, Seul Ki [VerfasserIn]
Kim, Shin Hee [VerfasserIn]
Cho, Won Kyoung [VerfasserIn]
Cho, Kyoung Soon [VerfasserIn]
Suh, Byung-Kyu [VerfasserIn]
Jung, Min Ho [VerfasserIn]

Links:

Volltext

Themen:

Adolescents
Child
Insulin resistance
Journal Article
Metabolic syndrome
Obesity

Anmerkungen:

Date Revised 15.01.2021

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.6065/apem.2040002.001

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM314446486