Combined imaging of potassium and sodium in human skeletal muscle tissue at 7 T
© 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine..
PURPOSE: To validate the feasibility of quantitative combined potassium (39 K) and sodium (23 Na) MRI in human calf muscle tissue, as well as to evaluate the reproducibility of the apparent tissue potassium concentration (aTPC) and apparent tissue sodium concentration (aTSC) determination in healthy muscle tissue.
METHODS: Quantitative 23 Na and 39 K MRI acquisition protocols were implemented on a 7 T MR system. A double-resonant 23 Na/39 K birdcage RF coil was used. Measurements of human lower leg were performed in a total acquisition time of TANa = 10:54 min/TAK = 8:06 min and using a nominal spatial resolution of 2.5 × 2.5 × 15 mm3 /7.5 × 7.5 × 30 mm3 for 23 Na/39 K MRI. Two aTSC and aTPC examinations in muscle tissue were performed during the same day on 10 healthy subjects.
RESULTS: The proposed acquisition and postprocessing workflow for 23 Na and 39 K MRI data sets provided reproducible aTSC and aTPC measurements. In human calf muscle tissue, the coefficient of variation between scan and re-scan was 5.7% for both aTSC and aTPC determination. Overall, mean values of aTSC = (17 ± 1) mM and aTPC = (85 ± 5) mM were measured. Moreover, for 39 K in calf muscle tissue, T2∗ components of T2f∗ = (1.2 ± 0.2) ms and T2s∗ = (7.9 ± 0.9) ms, as well as a residual quadrupolar interaction of ωq¯ = (143 ± 17) Hz, were determined. The fraction of the fast component was f = (58 ± 4)%.
CONCLUSION: Using the presented measurement and postprocessing approach, a reproducible aTSC and aTPC determination using 23 Na and 39 K MRI at 7 T in human skeletal muscle tissue is feasible in clinically acceptable acquisition durations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:85 |
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| Enthalten in: |
Magnetic resonance in medicine - 85(2021), 1 vom: 15. Jan., Seite 239-253 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gast, Lena V [VerfasserIn] |
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| Links: |
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| Themen: |
7 T |
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| Anmerkungen: |
Date Completed 10.05.2021 Date Revised 10.05.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/mrm.28428 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM314424237 |
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| 100 | 1 | |a Gast, Lena V |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Combined imaging of potassium and sodium in human skeletal muscle tissue at 7 T |
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| 500 | |a Date Revised 10.05.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. | ||
| 520 | |a PURPOSE: To validate the feasibility of quantitative combined potassium (39 K) and sodium (23 Na) MRI in human calf muscle tissue, as well as to evaluate the reproducibility of the apparent tissue potassium concentration (aTPC) and apparent tissue sodium concentration (aTSC) determination in healthy muscle tissue | ||
| 520 | |a METHODS: Quantitative 23 Na and 39 K MRI acquisition protocols were implemented on a 7 T MR system. A double-resonant 23 Na/39 K birdcage RF coil was used. Measurements of human lower leg were performed in a total acquisition time of TANa = 10:54 min/TAK = 8:06 min and using a nominal spatial resolution of 2.5 × 2.5 × 15 mm3 /7.5 × 7.5 × 30 mm3 for 23 Na/39 K MRI. Two aTSC and aTPC examinations in muscle tissue were performed during the same day on 10 healthy subjects | ||
| 520 | |a RESULTS: The proposed acquisition and postprocessing workflow for 23 Na and 39 K MRI data sets provided reproducible aTSC and aTPC measurements. In human calf muscle tissue, the coefficient of variation between scan and re-scan was 5.7% for both aTSC and aTPC determination. Overall, mean values of aTSC = (17 ± 1) mM and aTPC = (85 ± 5) mM were measured. Moreover, for 39 K in calf muscle tissue, T2∗ components of T2f∗ = (1.2 ± 0.2) ms and T2s∗ = (7.9 ± 0.9) ms, as well as a residual quadrupolar interaction of ωq¯ = (143 ± 17) Hz, were determined. The fraction of the fast component was f = (58 ± 4)% | ||
| 520 | |a CONCLUSION: Using the presented measurement and postprocessing approach, a reproducible aTSC and aTPC determination using 23 Na and 39 K MRI at 7 T in human skeletal muscle tissue is feasible in clinically acceptable acquisition durations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a 7 T | |
| 650 | 4 | |a potassium MRI | |
| 650 | 4 | |a sodium MRI | |
| 650 | 4 | |a tissue potassium concentration | |
| 650 | 4 | |a tissue sodium concentration | |
| 650 | 4 | |a ultrahigh field strengths | |
| 650 | 7 | |a Sodium |2 NLM | |
| 650 | 7 | |a 9NEZ333N27 |2 NLM | |
| 650 | 7 | |a Potassium |2 NLM | |
| 650 | 7 | |a RWP5GA015D |2 NLM | |
| 700 | 1 | |a Völker, Stefanie |e verfasserin |4 aut | |
| 700 | 1 | |a Utzschneider, Matthias |e verfasserin |4 aut | |
| 700 | 1 | |a Linz, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Wilferth, Tobias |e verfasserin |4 aut | |
| 700 | 1 | |a Müller, Max |e verfasserin |4 aut | |
| 700 | 1 | |a Kopp, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Hensel, Bernhard |e verfasserin |4 aut | |
| 700 | 1 | |a Uder, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Nagel, Armin M |e verfasserin |4 aut | |
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