A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria
This journal is © The Royal Society of Chemistry 2020..
Most existing photosensitizers (e.g., porphyrins) are often aggregated in aqueous solution because of their large conjugated molecular structures. This aggregation usually results in a lack or low levels of reactive oxygen species (ROS) generation due to aggregation-caused quenching, which severely hampers the application of photosensitizers in photodynamic therapy (PDT). Herein, we make an interesting finding that a boronic acid-functionalized phthalocyanine (PcN4-BA) displays an uncommon phenomenon, an aggregation-enhanced photodynamic effect. The combination of the ability to form uniform nanostructured self-assemblies in water, highly efficient ROS generation and boronic acid-induced targeting give PcN4-BA excellent performances in antimicrobial PDT.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Chemical science - 11(2020), 22 vom: 14. Juni, Seite 5735-5739 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Eunhye [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 28.09.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d0sc01351j |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM314372105 |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a This journal is © The Royal Society of Chemistry 2020. | ||
| 520 | |a Most existing photosensitizers (e.g., porphyrins) are often aggregated in aqueous solution because of their large conjugated molecular structures. This aggregation usually results in a lack or low levels of reactive oxygen species (ROS) generation due to aggregation-caused quenching, which severely hampers the application of photosensitizers in photodynamic therapy (PDT). Herein, we make an interesting finding that a boronic acid-functionalized phthalocyanine (PcN4-BA) displays an uncommon phenomenon, an aggregation-enhanced photodynamic effect. The combination of the ability to form uniform nanostructured self-assemblies in water, highly efficient ROS generation and boronic acid-induced targeting give PcN4-BA excellent performances in antimicrobial PDT | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Li, Xingshu |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Juwon |e verfasserin |4 aut | |
| 700 | 1 | |a Kwon, Nahyun |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Gyoungmi |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Dongho |e verfasserin |4 aut | |
| 700 | 1 | |a Yoon, Juyoung |e verfasserin |4 aut | |
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