Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases

Plants are a reservoir of high-value molecules with underexplored biomedical applications. With the aim of identifying novel health-promoting attributes in underexplored natural sources, we scrutinized the diversity of (poly)phenols present within the berries of selected germplasm from cultivated, wild, and underutilized Rubus species. Our strategy combined the application of metabolomics, statistical analysis, and evaluation of (poly)phenols' bioactivity using a yeast-based discovery platform. We identified species as sources of (poly)phenols interfering with pathological processes associated with redox-related diseases, particularly, amyotrophic lateral sclerosis, cancer, and inflammation. In silico prediction of putative bioactives suggested cyanidin-hexoside as an anti-inflammatory molecule which was validated in yeast and mammalian cells. Moreover, cellular assays revealed that the cyanidin moiety was responsible for the anti-inflammatory properties of cyanidin-hexoside. Our findings unveiled novel (poly)phenolic bioactivities and illustrated the power of our integrative approach for the identification of dietary (poly)phenols with potential biomedical applications.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:9

Enthalten in:

Antioxidants (Basel, Switzerland) - 9(2020), 9 vom: 26. Aug.

Sprache:

Englisch

Beteiligte Personen:

Menezes, Regina [VerfasserIn]
Foito, Alexandre [VerfasserIn]
Jardim, Carolina [VerfasserIn]
Costa, Inês [VerfasserIn]
Garcia, Gonçalo [VerfasserIn]
Rosado-Ramos, Rita [VerfasserIn]
Freitag, Sabine [VerfasserIn]
Alexander, Colin James [VerfasserIn]
Outeiro, Tiago Fleming [VerfasserIn]
Stewart, Derek [VerfasserIn]
Santos, Cláudia N [VerfasserIn]

Links:

Volltext

Themen:

(poly)phenols
Bioactivity-based assays
Cyanidin
Journal Article
Metabolomics
Rubus genus
Yeast-based discovery platform

Anmerkungen:

Date Revised 29.10.2020

published: Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.3390/antiox9090789

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM314320059