A putative role for the tobacco mosaic virus in smokers' resistance to COVID-19

Copyright © 2020 Elsevier Ltd. All rights reserved..

Reports from various countries suggest that tobacco smoking might protect from SARS-CoV-2 infection, since the prevalence of smoking in COVID-19 hospitalized patients is lower than in the respective general population. Apart from nicotine or other chemicals contained in tobacco smoke, we propose that a single-stranded RNA virus that infects tobacco leaves, tobacco mosaic virus (TMV), might be implicated in this effect. TMV, though non-pathogenic, is found in smokers' airways, and stimulates adaptive and innate immunity, with release of specific antibodies and interferons. The latter may have preventive and/or therapeutic effects against COVID-19. If confirmed by epidemiological and interventional studies, this might lead to the use of TMV as an immunological adjuvant against SARS-CoV-2 infection and COVID-19 disease.

Media Type:

Electronic Article

Year of Publication:

2020

Contained In:

Medical hypotheses - Vol. 143 (2020), p. 110153

Language:

English

Contributors:

de Bernardis, E
Busà, L

Links:

Volltext

Keywords:

*Models, Immunological
*Pandemics
*Smokers
*Tobacco Smoking
9008-11-1
Animals
Antibodies, Viral
Betacoronavirus
Coronavirus Infections
Disease Resistance
Humans
Interferons
Journal Article
Mice
Pneumonia, Viral
Respiratory System
Tobacco Mosaic Virus
Tobacco Products
Toll-Like Receptors

Notes:

Date Completed 13.10.2020

Date Revised 13.10.2020

published: Print-Electronic

Citation Status MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1016/j.mehy.2020.110153

PMID:

32763662

PPN (Catalogue-ID):

NLM314317740