Conventional autoantibodies against brain antigens are not routinely detectable in serum and CSF of narcolepsy type 1 and 2 patients

Copyright © 2020 Elsevier B.V. All rights reserved..

Narcolepsy with cataplexy (NT1) is a chronic hypothalamic disorder with a presumed immune-mediated etiology leading to a loss of hypocretin neurons. Previous studies reported conflicting results in terms of presence of auto-antibodies involved in narcolepsy pathophysiology. A total of 86 patients with primary/idiopathic narcolepsy (74 NT1, 12 NT2) and 23 control patients with excessive daytime sleepiness due to other causes were tested for the presence of a wide range of anti-neuronal antibodies in both serum and cerebrospinal fluid (CSF). Anti-neuronal antibodies were rarely found in patients with narcolepsy (n = 2) and in controls (n = 1). Our results are in line with previous reports. We can therefore support the current evidence, that conventional anti-neuronal antibodies are not routinely detected during the workup of NT1 and other CDH patients.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:75

Enthalten in:

Sleep medicine - 75(2020) vom: 30. Nov., Seite 188-191

Sprache:

Englisch

Beteiligte Personen:

Dietmann, Anelia [VerfasserIn]
Horn, Michael P [VerfasserIn]
Schinkelshoek, Mink S [VerfasserIn]
Fronczek, Rolf [VerfasserIn]
Salmen, Anke [VerfasserIn]
Bargiotas, Panagiotis [VerfasserIn]
Lammers, Gert J [VerfasserIn]
Khatami, Ramin [VerfasserIn]
Bassetti, Claudio L A [VerfasserIn]

Links:

Volltext

Themen:

Anti-neuronal antibodies
Autoantibodies
Journal Article
Narcolepsy borderland
Narcolepsy cataplexy
Narcolepsy type I
Orexins
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 21.06.2021

Date Revised 21.06.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.sleep.2020.08.001

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM314315594