Selenium and viral infection : are there lessons for COVID-19?

Se is a micronutrient essential for human health. Sub-optimal Se status is common, occurring in a significant proportion of the population across the world including parts of Europe and China. Human and animal studies have shown that Se status is a key determinant of the host response to viral infections. In this review, we address the question whether Se intake is a factor in determining the severity of response to coronavirus disease 2019 (COVID-19). Emphasis is placed on epidemiological and animal studies which suggest that Se affects host response to RNA viruses and on the molecular mechanisms by which Se and selenoproteins modulate the inter-linked redox homeostasis, stress response and inflammatory response. Together these studies indicate that Se status is an important factor in determining the host response to viral infections. Therefore, we conclude that Se status is likely to influence human response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and that Se status is one (of several) risk factors which may impact on the outcome of SARS-CoV-2 infection, particularly in populations where Se intake is sub-optimal or low. We suggest the use of appropriate markers to assess the Se status of COVID-19 patients and possible supplementation may be beneficial in limiting the severity of symptoms, especially in countries where Se status is regarded as sub-optimal.

Media Type:

Electronic Article

Year of Publication:

2021

Contained In:

The British journal of nutrition - Vol. 125, No. 6 (2021), p. 618-627

Language:

English

Contributors:

Bermano, Giovanna
Méplan, Catherine
Mercer, Derry K
Hesketh, John E

Links:

Volltext

Keywords:

Animals
COVID-19
H6241UJ22B
Humans
Inflammation
Journal Article
Micronutrients
Nutritional Status
Oxidation-Reduction
RNA, Viral
Redox status
Review
SARS-CoV-2
Selenium
Severe acute respiratory syndrome coronavirus 2
Stress, Physiological
Viral infection
Virus Diseases

Notes:

Date Completed 22.02.2021

Date Revised 22.02.2021

published: Print-Electronic

Citation Status MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1017/S0007114520003128

PMID:

32758306

PPN (Catalogue-ID):

NLM314264213