Establishment and evaluation of a risk-scoring system for lymph node metastasis in early-stage endometrial carcinoma : Achieving preoperative risk stratification
© 2020 Japan Society of Obstetrics and Gynecology..
AIM: To establish a risk-scoring system for lymph node metastasis (LNM) of early-stage endometrial carcinoma (EC), and to stratify the preoperative risk of LNM.
METHODS: We retrospectively analyzed the clinical data of 507 patients diagnosed with the early-stage EC (i.e., confined to the uterine corpus). We determined the risk factors for LNM by logistic regression analysis; then constructed a simple logistic scoring system, and an additive scoring system based on the regression coefficient (β), and odds ratio, of each variable, respectively.
RESULTS: The overall rate of LNM was 9.1% (46/507). Multivariate analysis showed that preoperative serum cancer antigen 125 (CA125) ≥35 U/mL, histopathology of grade 3 and/or type II, depth of myometrial invasion ≥1/2 and positive immunostaining for Ki-67 ≥50%, were independent risk factors for LNM (P < 0.05). The simple logistic and additive scoring systems exhibited good predictive ability (area under the curve [AUC] >0.8). Based on the additive scoring system, the risk of LNM in patients with early-stage EC was classified into three groups: a low-risk group (total score: <5), an intermediate-risk group (total score: 5-10) and a high-risk group (total score: >10). The incidence of LNM differed significantly across these three groups (P < 0.05).
CONCLUSION: The risk-scoring system constructed in this study can effectively predict the risk of LNM in patients with early-stage EC, achieve preoperative risk stratification and provide a reference guideline for the use of lymphadenectomy.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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Enthalten in: |
The journal of obstetrics and gynaecology research - 46(2020), 11 vom: 01. Nov., Seite 2305-2313 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Zhang, Ying [VerfasserIn] |
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Links: |
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Themen: |
Endometrial carcinoma |
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Anmerkungen: |
Date Completed 21.06.2021 Date Revised 21.06.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1111/jog.14422 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM314178678 |
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500 | |a Citation Status MEDLINE | ||
520 | |a © 2020 Japan Society of Obstetrics and Gynecology. | ||
520 | |a AIM: To establish a risk-scoring system for lymph node metastasis (LNM) of early-stage endometrial carcinoma (EC), and to stratify the preoperative risk of LNM | ||
520 | |a METHODS: We retrospectively analyzed the clinical data of 507 patients diagnosed with the early-stage EC (i.e., confined to the uterine corpus). We determined the risk factors for LNM by logistic regression analysis; then constructed a simple logistic scoring system, and an additive scoring system based on the regression coefficient (β), and odds ratio, of each variable, respectively | ||
520 | |a RESULTS: The overall rate of LNM was 9.1% (46/507). Multivariate analysis showed that preoperative serum cancer antigen 125 (CA125) ≥35 U/mL, histopathology of grade 3 and/or type II, depth of myometrial invasion ≥1/2 and positive immunostaining for Ki-67 ≥50%, were independent risk factors for LNM (P < 0.05). The simple logistic and additive scoring systems exhibited good predictive ability (area under the curve [AUC] >0.8). Based on the additive scoring system, the risk of LNM in patients with early-stage EC was classified into three groups: a low-risk group (total score: <5), an intermediate-risk group (total score: 5-10) and a high-risk group (total score: >10). The incidence of LNM differed significantly across these three groups (P < 0.05) | ||
520 | |a CONCLUSION: The risk-scoring system constructed in this study can effectively predict the risk of LNM in patients with early-stage EC, achieve preoperative risk stratification and provide a reference guideline for the use of lymphadenectomy | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a endometrial carcinoma | |
650 | 4 | |a lymph node metastasis | |
650 | 4 | |a risk stratification | |
650 | 4 | |a scoring system | |
700 | 1 | |a Zhao, Weidong |e verfasserin |4 aut | |
700 | 1 | |a Chen, Zhengzheng |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Xuxu |e verfasserin |4 aut | |
700 | 1 | |a Ren, Pingping |e verfasserin |4 aut | |
700 | 1 | |a Zhu, Meiling |e verfasserin |4 aut | |
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