Establishment and evaluation of a risk-scoring system for lymph node metastasis in early-stage endometrial carcinoma : Achieving preoperative risk stratification

© 2020 Japan Society of Obstetrics and Gynecology..

AIM: To establish a risk-scoring system for lymph node metastasis (LNM) of early-stage endometrial carcinoma (EC), and to stratify the preoperative risk of LNM.

METHODS: We retrospectively analyzed the clinical data of 507 patients diagnosed with the early-stage EC (i.e., confined to the uterine corpus). We determined the risk factors for LNM by logistic regression analysis; then constructed a simple logistic scoring system, and an additive scoring system based on the regression coefficient (β), and odds ratio, of each variable, respectively.

RESULTS: The overall rate of LNM was 9.1% (46/507). Multivariate analysis showed that preoperative serum cancer antigen 125 (CA125) ≥35 U/mL, histopathology of grade 3 and/or type II, depth of myometrial invasion ≥1/2 and positive immunostaining for Ki-67 ≥50%, were independent risk factors for LNM (P < 0.05). The simple logistic and additive scoring systems exhibited good predictive ability (area under the curve [AUC] >0.8). Based on the additive scoring system, the risk of LNM in patients with early-stage EC was classified into three groups: a low-risk group (total score: <5), an intermediate-risk group (total score: 5-10) and a high-risk group (total score: >10). The incidence of LNM differed significantly across these three groups (P < 0.05).

CONCLUSION: The risk-scoring system constructed in this study can effectively predict the risk of LNM in patients with early-stage EC, achieve preoperative risk stratification and provide a reference guideline for the use of lymphadenectomy.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:46

Enthalten in:

The journal of obstetrics and gynaecology research - 46(2020), 11 vom: 01. Nov., Seite 2305-2313

Sprache:

Englisch

Beteiligte Personen:

Zhang, Ying [VerfasserIn]
Zhao, Weidong [VerfasserIn]
Chen, Zhengzheng [VerfasserIn]
Zhao, Xuxu [VerfasserIn]
Ren, Pingping [VerfasserIn]
Zhu, Meiling [VerfasserIn]

Links:

Volltext

Themen:

Endometrial carcinoma
Journal Article
Lymph node metastasis
Risk stratification
Scoring system

Anmerkungen:

Date Completed 21.06.2021

Date Revised 21.06.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1111/jog.14422

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM314178678