Hemodynamics mediated epigenetic regulators in the pathogenesis of vascular diseases

Endothelium of blood vessels is continuously exposed to various hemodynamic forces. Flow-mediated epigenetic plasticity regulates vascular endothelial function. Recent studies have highlighted the significant role of mechanosensing-related epigenetics in localized endothelial dysfunction and the regional susceptibility for lesions in vascular diseases. In this article, we review the epigenetic mechanisms such as DNA de/methylation, histone modifications, as well as non-coding RNAs in promoting endothelial dysfunction in major arterial and venous diseases, consequent to hemodynamic alterations. We also discuss the current challenges and future prospects for the use of mechanoepigenetic mediators as biomarkers of early stages of vascular diseases and dysregulated mechanosensing-related epigenetic regulators as therapeutic targets in various vascular diseases.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:476

Enthalten in:

Molecular and cellular biochemistry - 476(2021), 1 vom: 26. Jan., Seite 125-143

Sprache:

Englisch

Beteiligte Personen:

Karthika, C L [VerfasserIn]
Ahalya, S [VerfasserIn]
Radhakrishnan, N [VerfasserIn]
Kartha, C C [VerfasserIn]
Sumi, S [VerfasserIn]

Links:

Volltext

Themen:

Atherosclerosis
Biomarkers
Endothelial cell
Epigenetics
Hemodynamics
Journal Article
Mechanosensor
Review
Venous disease

Anmerkungen:

Date Completed 12.07.2021

Date Revised 27.07.2023

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s11010-020-03890-9

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM314176888