The evolution of Tamiflu synthesis, 20 years on : Advent of enabling technologies the last piece of the puzzle?

© 2020 Elsevier Ltd. All rights reserved..

Influenza is a serious respiratory disease responsible for significant morbidity and mortality due to both annual epidemics and pandemics; its treatment involves the use of neuraminidase inhibitors. (-)-Oseltamivir phosphate (Tamiflu) approved in 1999, is one of the most potent oral anti-influenza neuraminidase inhibitors. Consequently, more than 70 Tamiflu synthetic procedures have been developed to date. Herein, we highlight the evolution of Tamiflu synthesis since its discovery over 20 years ago in the quest for a truly efficient, safe, cost-effective and environmentally benign synthetic procedure. We have selected a few representative routes to give a clear account of the past, present and the future with the advent of enabling technologies.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:76

Enthalten in:

Tetrahedron - 76(2020), 37 vom: 11. Sept., Seite 131440

Sprache:

Englisch

Beteiligte Personen:

Sagandira, Cloudius R [VerfasserIn]
Mathe, Francis M [VerfasserIn]
Guyo, Upenyu [VerfasserIn]
Watts, Paul [VerfasserIn]

Links:

Volltext

Themen:

Enabling technologies
Evolution
Influenza
Journal Article
Review
Tamiflu synthesis

Anmerkungen:

Date Revised 02.03.2023

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.1016/j.tet.2020.131440

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM314130608