Do nutrients and other bioactive molecules from foods have anything to say in the treatment against COVID-19?

Copyright © 2020 Elsevier Inc. All rights reserved..

The repositioning of therapeutic agents already approved by the regulatory agencies for the use of drugs is very interesting due to the immediacy of their use; similarly, the possibility of using molecules derived from foods, whether nutrients or not, is of great importance, also because of their immediate therapeutic applicability. Candidates for these natural therapies against COVID-19 should show certain effects, such as restoring mitochondrial function and cellular redox balance. This would allow reducing the susceptibility of risk groups and the cascade of events after SARS-CoV-2 infection, responsible for the clinical picture, triggered by the imbalance towards oxidation, inflammation, and cytokine storm. Possible strategies to follow through the use of substances of food origin would include: a) the promotion of mitophagy to remove dysfunctional mitochondria originating from free radicals, proton imbalance and virus evasion of the immune system; b) the administration of transition metals whose redox activity would lead to their own oxidation and the consequent generation of a reduced environment, which would normalize the oxidative state and the intracellular pH; c) the administration of molecules with demonstrated antioxidant capacity; d) the administration of compounds with anti-inflammatory and vasodilatory activity; e) the administration of immunomodulatory compounds.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:191

Enthalten in:

Environmental research - 191(2020) vom: 15. Dez., Seite 110053

Sprache:

Englisch

Beteiligte Personen:

Quiles, José L [VerfasserIn]
Rivas-García, Lorenzo [VerfasserIn]
Varela-López, Alfonso [VerfasserIn]
Llopis, Juan [VerfasserIn]
Battino, Maurizio [VerfasserIn]
Sánchez-González, Cristina [VerfasserIn]

Links:

Volltext

Themen:

Antioxidants
Curcumin
Journal Article
Polyphenols
Vitamin C
Vitamin D
Zinc

Anmerkungen:

Date Completed 19.11.2020

Date Revised 31.05.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.envres.2020.110053

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM314091300