Nucleotide-Selective Templated Self-Assembly of Nanoreactors under Dissipative Conditions

© 2020 Wiley-VCH GmbH..

Nature adopts complex chemical networks to finely tune biochemical processes. Indeed, small biomolecules play a key role in regulating the flux of metabolic pathways. Chemistry, which was traditionally focused on reactions in simple mixtures, is dedicating increasing attention to the network reactivity of highly complex synthetic systems, able to display new kinetic phenomena. Herein, we show that the addition of monophosphate nucleosides to a mixture of amphiphiles and reagents leads to the selective templated formation of self-assembled structures, which can accelerate a reaction between two hydrophobic reactants. The correct matching between nucleotide and the amphiphile head group is fundamental for the selective formation of the assemblies and for the consequent up-regulation of the chemical reaction. Transient stability of the nanoreactors is obtained under dissipative conditions, driven by enzymatic dephosphorylation of the templating nucleotides. These results show that small molecules can play a key role in modulating network reactivity, by selectively templating self-assembled structures that are able to up-regulate chemical reaction pathways.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:59

Enthalten in:

Angewandte Chemie (International ed. in English) - 59(2020), 49 vom: 01. Dez., Seite 22223-22229

Sprache:

Englisch

Beteiligte Personen:

Chandrabhas, Sushmitha [VerfasserIn]
Maiti, Subhabrata [VerfasserIn]
Fortunati, Ilaria [VerfasserIn]
Ferrante, Camilla [VerfasserIn]
Gabrielli, Luca [VerfasserIn]
Prins, Leonard J [VerfasserIn]

Links:

Volltext

Themen:

Amphiphiles
Journal Article
Molecular recognition
Network reactivity
Research Support, Non-U.S. Gov't
Self-assembly
Systems chemistry

Anmerkungen:

Date Completed 16.12.2020

Date Revised 16.12.2020

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.1002/anie.202010199

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM314067124