Resting-State Isolated Effective Connectivity of the Cingulate Cortex as a Neurophysiological Biomarker in Patients with Severe Treatment-Resistant Schizophrenia

Background: The neural basis of treatment-resistant schizophrenia (TRS) remains unclear. Previous neuroimaging studies suggest that aberrant connectivity between the anterior cingulate cortex (ACC) and default mode network (DMN) may play a key role in the pathophysiology of TRS. Thus, we aimed to examine the connectivity between the ACC and posterior cingulate cortex (PCC), a hub of the DMN, computing isolated effective coherence (iCoh), which represents causal effective connectivity. Methods: Resting-state electroencephalogram with 19 channels was acquired from seventeen patients with TRS and thirty patients with non-TRS (nTRS). The iCoh values between the PCC and ACC were calculated using sLORETA software. We conducted four-way analyses of variance (ANOVAs) for iCoh values with group as a between-subject factor and frequency, directionality, and laterality as within-subject factors and post-hoc independent t-tests. Results: The ANOVA and post-hoc t-tests for the iCoh ratio of directionality from PCC to ACC showed significant findings in delta (t45 = 7.659, p = 0.008) and theta (t45 = 8.066, p = 0.007) bands in the left side (TRS < nTRS). Conclusion: Left delta and theta PCC and ACC iCoh ratio may represent a neurophysiological basis of TRS. Given the preliminary nature of this study, these results warrant further study to confirm the importance of iCoh as a clinical indicator for treatment-resistance.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:10

Enthalten in:

Journal of personalized medicine - 10(2020), 3 vom: 14. Aug.

Sprache:

Englisch

Beteiligte Personen:

Wada, Masataka [VerfasserIn]
Nakajima, Shinichiro [VerfasserIn]
Tarumi, Ryosuke [VerfasserIn]
Masuda, Fumi [VerfasserIn]
Miyazaki, Takahiro [VerfasserIn]
Tsugawa, Sakiko [VerfasserIn]
Ogyu, Kamiyu [VerfasserIn]
Honda, Shiori [VerfasserIn]
Matsushita, Karin [VerfasserIn]
Kikuchi, Yudai [VerfasserIn]
Fujii, Shinya [VerfasserIn]
Blumberger, Daniel M [VerfasserIn]
Daskalakis, Zafiris J [VerfasserIn]
Mimura, Masaru [VerfasserIn]
Noda, Yoshihiro [VerfasserIn]

Links:

Volltext

Themen:

Anterior cingulate cortex
Causal effective connectivity
Default mode network
Isolated effective coherence
Journal Article
Posterior cingulate cortex
Resting-state electroencephalography
Treatment-resistant schizophrenia

Anmerkungen:

Date Revised 30.10.2020

published: Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.3390/jpm10030089

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM313976325