Resting-State Isolated Effective Connectivity of the Cingulate Cortex as a Neurophysiological Biomarker in Patients with Severe Treatment-Resistant Schizophrenia
Background: The neural basis of treatment-resistant schizophrenia (TRS) remains unclear. Previous neuroimaging studies suggest that aberrant connectivity between the anterior cingulate cortex (ACC) and default mode network (DMN) may play a key role in the pathophysiology of TRS. Thus, we aimed to examine the connectivity between the ACC and posterior cingulate cortex (PCC), a hub of the DMN, computing isolated effective coherence (iCoh), which represents causal effective connectivity. Methods: Resting-state electroencephalogram with 19 channels was acquired from seventeen patients with TRS and thirty patients with non-TRS (nTRS). The iCoh values between the PCC and ACC were calculated using sLORETA software. We conducted four-way analyses of variance (ANOVAs) for iCoh values with group as a between-subject factor and frequency, directionality, and laterality as within-subject factors and post-hoc independent t-tests. Results: The ANOVA and post-hoc t-tests for the iCoh ratio of directionality from PCC to ACC showed significant findings in delta (t45 = 7.659, p = 0.008) and theta (t45 = 8.066, p = 0.007) bands in the left side (TRS < nTRS). Conclusion: Left delta and theta PCC and ACC iCoh ratio may represent a neurophysiological basis of TRS. Given the preliminary nature of this study, these results warrant further study to confirm the importance of iCoh as a clinical indicator for treatment-resistance.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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Enthalten in: |
Journal of personalized medicine - 10(2020), 3 vom: 14. Aug. |
Sprache: |
Englisch |
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Beteiligte Personen: |
Wada, Masataka [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Revised 30.10.2020 published: Electronic Citation Status PubMed-not-MEDLINE |
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doi: |
10.3390/jpm10030089 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM313976325 |
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520 | |a Background: The neural basis of treatment-resistant schizophrenia (TRS) remains unclear. Previous neuroimaging studies suggest that aberrant connectivity between the anterior cingulate cortex (ACC) and default mode network (DMN) may play a key role in the pathophysiology of TRS. Thus, we aimed to examine the connectivity between the ACC and posterior cingulate cortex (PCC), a hub of the DMN, computing isolated effective coherence (iCoh), which represents causal effective connectivity. Methods: Resting-state electroencephalogram with 19 channels was acquired from seventeen patients with TRS and thirty patients with non-TRS (nTRS). The iCoh values between the PCC and ACC were calculated using sLORETA software. We conducted four-way analyses of variance (ANOVAs) for iCoh values with group as a between-subject factor and frequency, directionality, and laterality as within-subject factors and post-hoc independent t-tests. Results: The ANOVA and post-hoc t-tests for the iCoh ratio of directionality from PCC to ACC showed significant findings in delta (t45 = 7.659, p = 0.008) and theta (t45 = 8.066, p = 0.007) bands in the left side (TRS < nTRS). Conclusion: Left delta and theta PCC and ACC iCoh ratio may represent a neurophysiological basis of TRS. Given the preliminary nature of this study, these results warrant further study to confirm the importance of iCoh as a clinical indicator for treatment-resistance | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a anterior cingulate cortex | |
650 | 4 | |a causal effective connectivity | |
650 | 4 | |a default mode network | |
650 | 4 | |a isolated effective coherence | |
650 | 4 | |a posterior cingulate cortex | |
650 | 4 | |a resting-state electroencephalography | |
650 | 4 | |a treatment-resistant schizophrenia | |
700 | 1 | |a Nakajima, Shinichiro |e verfasserin |4 aut | |
700 | 1 | |a Tarumi, Ryosuke |e verfasserin |4 aut | |
700 | 1 | |a Masuda, Fumi |e verfasserin |4 aut | |
700 | 1 | |a Miyazaki, Takahiro |e verfasserin |4 aut | |
700 | 1 | |a Tsugawa, Sakiko |e verfasserin |4 aut | |
700 | 1 | |a Ogyu, Kamiyu |e verfasserin |4 aut | |
700 | 1 | |a Honda, Shiori |e verfasserin |4 aut | |
700 | 1 | |a Matsushita, Karin |e verfasserin |4 aut | |
700 | 1 | |a Kikuchi, Yudai |e verfasserin |4 aut | |
700 | 1 | |a Fujii, Shinya |e verfasserin |4 aut | |
700 | 1 | |a Blumberger, Daniel M |e verfasserin |4 aut | |
700 | 1 | |a Daskalakis, Zafiris J |e verfasserin |4 aut | |
700 | 1 | |a Mimura, Masaru |e verfasserin |4 aut | |
700 | 1 | |a Noda, Yoshihiro |e verfasserin |4 aut | |
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