Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer : A Systematic Review

There is an unmet need for novel non-invasive prognostic molecular tumour markers for breast cancer (BC). Accumulating evidence shows that miR-155 plays a pivotal role in tumorigenesis. Generally, miR-155 is considered an oncogenic miRNA promoting tumour growth, angiogenesis and aggressiveness of BC. Therefore, many researchers have focused on its use as a prognostic biomarker and therapeutic target. However, its prognostic value for BC patients remains controversial. To address this issue, the present systematic review aims to summarize the available evidence and give a picture of a prognostic significance of miR-155 in BC pathology. All eligible studies were searched on PubMed and EMBASE databases through various search strategies. Starting from 289 potential eligible records, data were examined from 28 studies, comparing tissue and circulating miR-155 expression levels with clinicopathological features and survival rates in BC patients. We discuss the pitfalls and challenges that need to be assessed to understand the power of miR-155 to respond to real clinical needs, highlighting the consistency, robustness or lack of results obtained to sate in translating this molecule to clinical practice. Our paper suggests that the prognostic role of miR-155 in the management of BC needs to be further verified.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:21

Enthalten in:

International journal of molecular sciences - 21(2020), 16 vom: 14. Aug.

Sprache:

Englisch

Beteiligte Personen:

Grimaldi, Anna Maria [VerfasserIn]
Nuzzo, Silvia [VerfasserIn]
Condorelli, Gerolama [VerfasserIn]
Salvatore, Marco [VerfasserIn]
Incoronato, Mariarosaria [VerfasserIn]

Links:

Volltext

Themen:

Biomarkers, Tumor
Breast cancer
Circulating
Diagnosis
Journal Article
MIRN155 microRNA, human
MiR-155
MicroRNA
MicroRNAs
Prognosis
Systematic Review
Tissue

Anmerkungen:

Date Completed 18.02.2021

Date Revised 18.02.2021

published: Electronic

Citation Status MEDLINE

doi:

10.3390/ijms21165834

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM313975825