The Absence of Adiponectin Alters Niacin's Effects on Adipose Tissue Inflammation in Mice

Obesity is an immunometabolic disease associated with chronic inflammation and the dysregulation of pro- and anti-inflammatory cytokines. One hallmark of obesity is reduced concentrations of the anti-inflammatory adipokine, adiponectin. Pharmacologic doses of niacin produce multiple metabolic benefits, including attenuating high-fat diet (HFD)-induced adipose tissue inflammation and increasing adiponectin concentrations. To determine if adiponectin mediates the anti-inflammatory effects of niacin, male C57BL/6J (WT) and adiponectin null (Adipoq-/-) mice were maintained on a low-fat diet (LFD) or HFD for 6 weeks, before being administered either vehicle or niacin (360 mg/kg/day) for 5 weeks. HFD-fed mice had increased expression of genes associated with macrophage recruitment (Ccl2) and number (Cd68), and increased crown-like structure (CLS) number in adipose tissue. While niacin attenuated Ccl2 expression, there were no effects on Cd68 or CLS number. The absence of adiponectin did not hinder the ability of niacin to reduce Ccl2 expression. HFD feeding increased gene expression of inflammatory markers in the adipose tissue of WT and Adipoq-/- mice. While niacin tended to decrease the expression of inflammatory markers in WT mice, niacin increased their expression in HFD-fed Adipoq-/- mice. Therefore, our results indicate that the absence of adiponectin alters the effects of niacin on markers of adipose tissue inflammation in HFD-fed mice, suggesting that the effects of niacin on tissue cytokines may involve adiponectin.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:12

Enthalten in:

Nutrients - 12(2020), 8 vom: 13. Aug.

Sprache:

Englisch

Beteiligte Personen:

Graff, Emily C [VerfasserIn]
Fang, Han [VerfasserIn]
Wanders, Desiree [VerfasserIn]
Judd, Robert L [VerfasserIn]

Links:

Volltext

Themen:

2679MF687A
Adipokines
Adiponectin
Anti-Inflammatory Agents
Antigens, CD
Antigens, Differentiation, Myelomonocytic
CD68 protein, mouse
Ccl2 protein, mouse
Chemokine CCL2
Cytokines
Immune
Inflammation
Journal Article
Niacin
Obesity

Anmerkungen:

Date Completed 17.03.2021

Date Revised 17.03.2021

published: Electronic

Citation Status MEDLINE

doi:

10.3390/nu12082427

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM313972591