The Absence of Adiponectin Alters Niacin's Effects on Adipose Tissue Inflammation in Mice
Obesity is an immunometabolic disease associated with chronic inflammation and the dysregulation of pro- and anti-inflammatory cytokines. One hallmark of obesity is reduced concentrations of the anti-inflammatory adipokine, adiponectin. Pharmacologic doses of niacin produce multiple metabolic benefits, including attenuating high-fat diet (HFD)-induced adipose tissue inflammation and increasing adiponectin concentrations. To determine if adiponectin mediates the anti-inflammatory effects of niacin, male C57BL/6J (WT) and adiponectin null (Adipoq-/-) mice were maintained on a low-fat diet (LFD) or HFD for 6 weeks, before being administered either vehicle or niacin (360 mg/kg/day) for 5 weeks. HFD-fed mice had increased expression of genes associated with macrophage recruitment (Ccl2) and number (Cd68), and increased crown-like structure (CLS) number in adipose tissue. While niacin attenuated Ccl2 expression, there were no effects on Cd68 or CLS number. The absence of adiponectin did not hinder the ability of niacin to reduce Ccl2 expression. HFD feeding increased gene expression of inflammatory markers in the adipose tissue of WT and Adipoq-/- mice. While niacin tended to decrease the expression of inflammatory markers in WT mice, niacin increased their expression in HFD-fed Adipoq-/- mice. Therefore, our results indicate that the absence of adiponectin alters the effects of niacin on markers of adipose tissue inflammation in HFD-fed mice, suggesting that the effects of niacin on tissue cytokines may involve adiponectin.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
---|---|
Enthalten in: |
Nutrients - 12(2020), 8 vom: 13. Aug. |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Graff, Emily C [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 17.03.2021 Date Revised 17.03.2021 published: Electronic Citation Status MEDLINE |
---|
doi: |
10.3390/nu12082427 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM313972591 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM313972591 | ||
003 | DE-627 | ||
005 | 20231225151727.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3390/nu12082427 |2 doi | |
028 | 5 | 2 | |a pubmed24n1046.xml |
035 | |a (DE-627)NLM313972591 | ||
035 | |a (NLM)32823541 | ||
035 | |a (PII)E2427 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Graff, Emily C |e verfasserin |4 aut | |
245 | 1 | 4 | |a The Absence of Adiponectin Alters Niacin's Effects on Adipose Tissue Inflammation in Mice |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 17.03.2021 | ||
500 | |a Date Revised 17.03.2021 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Obesity is an immunometabolic disease associated with chronic inflammation and the dysregulation of pro- and anti-inflammatory cytokines. One hallmark of obesity is reduced concentrations of the anti-inflammatory adipokine, adiponectin. Pharmacologic doses of niacin produce multiple metabolic benefits, including attenuating high-fat diet (HFD)-induced adipose tissue inflammation and increasing adiponectin concentrations. To determine if adiponectin mediates the anti-inflammatory effects of niacin, male C57BL/6J (WT) and adiponectin null (Adipoq-/-) mice were maintained on a low-fat diet (LFD) or HFD for 6 weeks, before being administered either vehicle or niacin (360 mg/kg/day) for 5 weeks. HFD-fed mice had increased expression of genes associated with macrophage recruitment (Ccl2) and number (Cd68), and increased crown-like structure (CLS) number in adipose tissue. While niacin attenuated Ccl2 expression, there were no effects on Cd68 or CLS number. The absence of adiponectin did not hinder the ability of niacin to reduce Ccl2 expression. HFD feeding increased gene expression of inflammatory markers in the adipose tissue of WT and Adipoq-/- mice. While niacin tended to decrease the expression of inflammatory markers in WT mice, niacin increased their expression in HFD-fed Adipoq-/- mice. Therefore, our results indicate that the absence of adiponectin alters the effects of niacin on markers of adipose tissue inflammation in HFD-fed mice, suggesting that the effects of niacin on tissue cytokines may involve adiponectin | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a adipokines | |
650 | 4 | |a immune | |
650 | 4 | |a inflammation | |
650 | 4 | |a niacin | |
650 | 4 | |a obesity | |
650 | 7 | |a Adiponectin |2 NLM | |
650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
650 | 7 | |a Antigens, CD |2 NLM | |
650 | 7 | |a Antigens, Differentiation, Myelomonocytic |2 NLM | |
650 | 7 | |a CD68 protein, mouse |2 NLM | |
650 | 7 | |a Ccl2 protein, mouse |2 NLM | |
650 | 7 | |a Chemokine CCL2 |2 NLM | |
650 | 7 | |a Cytokines |2 NLM | |
650 | 7 | |a Niacin |2 NLM | |
650 | 7 | |a 2679MF687A |2 NLM | |
700 | 1 | |a Fang, Han |e verfasserin |4 aut | |
700 | 1 | |a Wanders, Desiree |e verfasserin |4 aut | |
700 | 1 | |a Judd, Robert L |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Nutrients |d 2009 |g 12(2020), 8 vom: 13. Aug. |w (DE-627)NLM206140738 |x 2072-6643 |7 nnns |
773 | 1 | 8 | |g volume:12 |g year:2020 |g number:8 |g day:13 |g month:08 |
856 | 4 | 0 | |u http://dx.doi.org/10.3390/nu12082427 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 12 |j 2020 |e 8 |b 13 |c 08 |