Systemic immunosuppressive therapies for uveitis in developing countries

There are multiple approaches to inhibit inflammatory molecules and pathways in noninfectious uveitis. The cornerstone of local and systemic anti-inflammatory treatment is corticosteroid therapy. Corticosteroids remain the most potent and efficacious drugs for treating intraocular inflammation. However, their long-term use is limited by their medium- and long-term side effects, which are a major concern. The approach taken to limit corticosteroid side effects is to introduce steroid-sparing agents that suppress the inflammatory pathways and immune response differently than corticosteroids. There are several classes of such drugs that are affordable, effective, and generally well-tolerated. Relatively recently, an increasing range of biologic agents has become available to treat intraocular inflammation. However, the relatively expensive cost of these therapies limits their use in the developing world. This systemic review aimst to discuss the use of corticosteroids and different immunosuppressive regimens in the management of various uveitides.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:68

Enthalten in:

Indian journal of ophthalmology - 68(2020), 9 vom: 01. Sept., Seite 1852-1862

Sprache:

Englisch

Beteiligte Personen:

Agrawal, Hitesh [VerfasserIn]
Doan, Hien [VerfasserIn]
Pham, Brandon [VerfasserIn]
Khosla, Amit [VerfasserIn]
Babu, Manohar [VerfasserIn]
McCluskey, Peter [VerfasserIn]
Nguyen, Quan Dong [VerfasserIn]
Sangwan, Virender [VerfasserIn]
Reddy, Subhakar [VerfasserIn]
Sawhney, Sujata [VerfasserIn]
Tyagi, Mudit [VerfasserIn]

Links:

Volltext

Themen:

Adrenal Cortex Hormones
Biologicals
Corticosteroids
Immunosuppression
Immunosuppressive Agents
Inflammation
Journal Article
Non infectious uveitis
Review

Anmerkungen:

Date Completed 14.05.2021

Date Revised 04.12.2021

published: Print

Citation Status MEDLINE

doi:

10.4103/ijo.IJO_1548_20

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM313971234