Fractalkine-Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved..

Oligodendrogenesis occurs during early postnatal development, coincident with neurogenesis and synaptogenesis, raising the possibility that microglia-dependent pruning mechanisms that modulate neurons regulate myelin sheath formation. Here we show a population of ameboid microglia migrating from the ventricular zone into the corpus callosum during early postnatal development, termed "the fountain of microglia," phagocytosing viable oligodendrocyte progenitor cells (OPCs) before onset of myelination. Fractalkine receptor-deficient mice exhibit a reduction in microglial engulfment of viable OPCs, increased numbers of oligodendrocytes, and reduced myelin thickness but no change in axon number. These data provide evidence that microglia phagocytose OPCs as a homeostatic mechanism for proper myelination. A hallmark of hypomyelinating developmental disorders such as periventricular leukomalacia and of adult demyelinating diseases such as multiple sclerosis is increased numbers of oligodendrocytes but failure to myelinate, suggesting that microglial pruning of OPCs may be impaired in pathological states and hinder myelination.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:32

Enthalten in:

Cell reports - 32(2020), 7 vom: 18. Aug., Seite 108047

Sprache:

Englisch

Beteiligte Personen:

Nemes-Baran, Ashley D [VerfasserIn]
White, Donovan R [VerfasserIn]
DeSilva, Tara M [VerfasserIn]

Links:

Volltext

Themen:

Engulfment
Fractalkine receptor
Journal Article
Microglia
Myelin
Oligodendrocyte
Oligodendrocyte progenitor cell
Phagocytosis
Phagoptosis
Pruning
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
White matter development

Anmerkungen:

Date Completed 28.05.2021

Date Revised 28.05.2021

published: Print

Citation Status MEDLINE

doi:

10.1016/j.celrep.2020.108047

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM313879419