Serial serum SARS-CoV-2 RNA results in two COVID-19 cases with severe respiratory failure
Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved..
Coronavirus disease 2019 (COVID-19) is spreading worldwide and poses an imminent threat to public health. We encountered 2 cases of COVID-19 with progression resulting in severe respiratory failure and improvement without any specific treatment. To examine the course of infection, we performed reverse-transcription (RT) polymerase chain reaction assay with serum specimens, and serum SARS-CoV-2 RNA was detected in both cases when body temperature increased and respiratory status deteriorated. We, then examined, retrospectively and prospectively, the clinical course during hospitalization by performing serial examinations of serum SARS-CoV-2 RNA status. The findings from our cases suggest that not only is detection of viremia useful as a predictive marker of severity, but also serial serum SARS-CoV-2 RNA results can be helpful for predicting the clinical course.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 26(2020), 11 vom: 10. Nov., Seite 1220-1223 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kodama, Tatsuya [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 14.09.2020 Date Revised 10.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jiac.2020.07.003 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313669228 |
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| 245 | 1 | 0 | |a Serial serum SARS-CoV-2 RNA results in two COVID-19 cases with severe respiratory failure |
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| 520 | |a Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a Coronavirus disease 2019 (COVID-19) is spreading worldwide and poses an imminent threat to public health. We encountered 2 cases of COVID-19 with progression resulting in severe respiratory failure and improvement without any specific treatment. To examine the course of infection, we performed reverse-transcription (RT) polymerase chain reaction assay with serum specimens, and serum SARS-CoV-2 RNA was detected in both cases when body temperature increased and respiratory status deteriorated. We, then examined, retrospectively and prospectively, the clinical course during hospitalization by performing serial examinations of serum SARS-CoV-2 RNA status. The findings from our cases suggest that not only is detection of viremia useful as a predictive marker of severity, but also serial serum SARS-CoV-2 RNA results can be helpful for predicting the clinical course | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Serum SARS-CoV-2 RNA | |
| 650 | 4 | |a Severe respiratory failure | |
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| 700 | 1 | |a Kouzaki, Yuji |e verfasserin |4 aut | |
| 700 | 1 | |a Kawano, Shuichi |e verfasserin |4 aut | |
| 700 | 1 | |a Obinata, Hirofumi |e verfasserin |4 aut | |
| 700 | 1 | |a Taniguchi, Hiroaki |e verfasserin |4 aut | |
| 700 | 1 | |a Sasaki, Hisashi |e verfasserin |4 aut | |
| 700 | 1 | |a Ota, Shinichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kawana, Akihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Tamura, Kaku |e verfasserin |4 aut | |
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