Pleural translocation and lesions by pulmonary exposed multi-walled carbon nanotubes

©2020 The Japanese Society of Toxicologic Pathology..

Carbon nanotubes (CNTs) are recently developed tubular nanomaterials, with diameters ranging from a few nanometers to tens of nanometers, and the length reaching up to several micrometers. They can be either single-walled carbon nanotubes (SWCNTs) or multi-walled carbon nanotubes (MWCNTs). Due to their nano-scaled structure, CNTs have a unique set of mechanical, electrical, and chemical properties that make them useful in information technologies, optoelectronics, energy technologies, material sciences, medical technologies, and other fields. However, with the wide application and increasing production of CNTs, their potential risks have led to concerns regarding their impact on environment and health. The shape of some types of CNTs is similar to asbestos fibers, which suggests that these CNTs may cause characteristic pleural diseases similar to those found in asbestos-exposed humans, such as pleural plaques and malignant mesothelioma. Experimental data indicate that CNTs can induce lung and pleural lesions, inflammation, pleural fibrosis, lung tumors, and malignant mesothelioma upon inhalation in the experimental animals. In this review, we focus on the potential of MWCNTs to induce diseases similar to those by asbestos, molecular and cellular mechanisms associated with these diseases, and we discuss a method for evaluating the pleural toxicity of MWCNTs.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:33

Enthalten in:

Journal of toxicologic pathology - 33(2020), 3 vom: 14. Juli, Seite 145-151

Sprache:

Englisch

Beteiligte Personen:

Wang, Qiong [VerfasserIn]
Wang, Qiqi [VerfasserIn]
Zhao, Ziyue [VerfasserIn]
Alexander, David B [VerfasserIn]
Zhao, Dahai [VerfasserIn]
Xu, Jiegou [VerfasserIn]
Tsuda, Hiroyuki [VerfasserIn]

Links:

Volltext

Themen:

Asbestos
Journal Article
Multi-walled carbon nanotubes
Pleural lesions
Pleural translocation
Review

Anmerkungen:

Date Revised 28.09.2020

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.1293/tox.2019-0075

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM313398801