Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6
© 2020, Coré et al..
Different subtypes of interneurons, destined for the olfactory bulb, are continuously generated by neural stem cells located in the ventricular and subventricular zones along the lateral forebrain ventricles of mice. Neuronal identity in the olfactory bulb depends on the existence of defined microdomains of pre-determined neural stem cells along the ventricle walls. The molecular mechanisms underlying positional identity of these neural stem cells are poorly understood. Here, we show that the transcription factor Vax1 controls the production of two specific neuronal subtypes. First, it is directly necessary to generate Calbindin expressing interneurons from ventro-lateral progenitors. Second, it represses the generation of dopaminergic neurons by dorsolateral progenitors through inhibition of Pax6 expression. We present data indicating that this repression occurs, at least in part, via activation of microRNA miR-7.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
eLife - 9(2020) vom: 07. Aug. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Coré, Nathalie [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 24.02.2021 Date Revised 15.04.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.7554/eLife.58215 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313379130 |
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| 245 | 1 | 0 | |a Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6 |
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| 500 | |a Date Revised 15.04.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020, Coré et al. | ||
| 520 | |a Different subtypes of interneurons, destined for the olfactory bulb, are continuously generated by neural stem cells located in the ventricular and subventricular zones along the lateral forebrain ventricles of mice. Neuronal identity in the olfactory bulb depends on the existence of defined microdomains of pre-determined neural stem cells along the ventricle walls. The molecular mechanisms underlying positional identity of these neural stem cells are poorly understood. Here, we show that the transcription factor Vax1 controls the production of two specific neuronal subtypes. First, it is directly necessary to generate Calbindin expressing interneurons from ventro-lateral progenitors. Second, it represses the generation of dopaminergic neurons by dorsolateral progenitors through inhibition of Pax6 expression. We present data indicating that this repression occurs, at least in part, via activation of microRNA miR-7 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a developmental biology | |
| 650 | 4 | |a miRNA | |
| 650 | 4 | |a mouse | |
| 650 | 4 | |a neural stem cells | |
| 650 | 4 | |a neuroscience | |
| 650 | 4 | |a olfactory bulb interneurons | |
| 650 | 4 | |a postnatal neurogenesis | |
| 650 | 4 | |a regulatory interactions | |
| 650 | 4 | |a transcription factors | |
| 650 | 7 | |a Calbindins |2 NLM | |
| 650 | 7 | |a Homeodomain Proteins |2 NLM | |
| 650 | 7 | |a MIRN7 microRNA, mouse |2 NLM | |
| 650 | 7 | |a MicroRNAs |2 NLM | |
| 650 | 7 | |a Neuropeptides |2 NLM | |
| 650 | 7 | |a PAX6 Transcription Factor |2 NLM | |
| 650 | 7 | |a Pax6 protein, mouse |2 NLM | |
| 650 | 7 | |a Vax1 protein, mouse |2 NLM | |
| 700 | 1 | |a Erni, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Hoffmann, Hanne M |e verfasserin |4 aut | |
| 700 | 1 | |a Mellon, Pamela L |e verfasserin |4 aut | |
| 700 | 1 | |a Saurin, Andrew J |e verfasserin |4 aut | |
| 700 | 1 | |a Beclin, Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Cremer, Harold |e verfasserin |4 aut | |
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