Comparisons of Risk Factors for Abdominal Aortic Aneurysm and Coronary Heart Disease : A Prospective Cohort Study

Even though abdominal aortic aneurysm (AAA) and coronary heart disease (CHD) are both related to atherosclerosis, there could be important differences in risk factors. Based on Malmö Diet and Cancer Cohort, the incidence of AAA and CHD was followed prospectively. Cox regression was used to calculate the association of each factor with AAA and CHD and hazards ratio were compared using a modified Lunn-McNeil method; 447 participants developed AAA and 3129 developed CHD. After multivariate adjustments, smoking, antihypertensive medications, lipid-lowing medications, systolic and diastolic blood pressures, apolipoprotein (Apo) A1 (inversely), ApoB, ApoB/ApoA1 ratio, total leukocyte count, neutrophil count, and neutrophil to lymphocyte ratio were associated with the risks of both AAA and CHD. When comparing risk factor profiles for the 2 diseases, smoking, diastolic blood pressure, ApoA1, and ApoB/ApoA1 ratio had stronger associations with risk of AAA than with risk of CHD, while diabetes and unmarried status showed increased risk of CHD, but not of AAA (all P values for equal association <.01). The results from this big population study confirm that the risk factor profiles for AAA and CHD show not only many similarities but also several important differences.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:72

Enthalten in:

Angiology - 72(2021), 1 vom: 31. Jan., Seite 24-31

Sprache:

Englisch

Beteiligte Personen:

Xiao, Jun [VerfasserIn]
Borné, Yan [VerfasserIn]
Bao, Xue [VerfasserIn]
Persson, Margaretha [VerfasserIn]
Gottsäter, Anders [VerfasserIn]
Acosta, Stefan [VerfasserIn]
Engström, Gunnar [VerfasserIn]

Links:

Volltext

Themen:

APOA1 protein, human
Abdominal aortic aneurysm
Apolipoprotein A-I
Apolipoproteins B
Coronary heart disease
Diabetes mellitus
Journal Article
Proportional hazards models
Research Support, Non-U.S. Gov't
Smoking

Anmerkungen:

Date Completed 11.01.2021

Date Revised 04.02.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1177/0003319720946976

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM313374260