Biocompatibility evaluation of heparin-conjugated poly(ε-caprolactone) scaffolds in a rat subcutaneous implantation model
Vascular grafts prepared from synthetic polymers have serious shortcomings that can be resolved by surface modification, such as by immobilizing heparin. In this study, the mechanical properties, biocompatibility, anticoagulation property, and water contact angle of two heparin-conjugated poly(ε-caprolactone) scaffolds (PCL-hexamethylendiamine-heparin, PCL-HMD-H. PCL-lysine-heparin, PCL-LYS-H) were compared to identify a preferred heparin conjugation method. An evaluation of the subcutaneous tissue biocompatibility of the scaffolds demonstrated that PCL-HMD-H had better endothelial cell proliferation than the PCL-LYS-H and was therefore a promising scaffold candidate for use in vascular tissue-engineering.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
|---|---|
| Enthalten in: |
Journal of materials science. Materials in medicine - 31(2020), 8 vom: 05. Aug., Seite 76 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Xu, Zeqin [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
24980-41-4 |
|---|
| Anmerkungen: |
Date Completed 28.06.2021 Date Revised 28.06.2021 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s10856-020-06419-0 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM313363544 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM313363544 | ||
| 003 | DE-627 | ||
| 005 | 20231225150420.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10856-020-06419-0 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1044.xml |
| 035 | |a (DE-627)NLM313363544 | ||
| 035 | |a (NLM)32761269 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Xu, Zeqin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Biocompatibility evaluation of heparin-conjugated poly(ε-caprolactone) scaffolds in a rat subcutaneous implantation model |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 28.06.2021 | ||
| 500 | |a Date Revised 28.06.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Vascular grafts prepared from synthetic polymers have serious shortcomings that can be resolved by surface modification, such as by immobilizing heparin. In this study, the mechanical properties, biocompatibility, anticoagulation property, and water contact angle of two heparin-conjugated poly(ε-caprolactone) scaffolds (PCL-hexamethylendiamine-heparin, PCL-HMD-H. PCL-lysine-heparin, PCL-LYS-H) were compared to identify a preferred heparin conjugation method. An evaluation of the subcutaneous tissue biocompatibility of the scaffolds demonstrated that PCL-HMD-H had better endothelial cell proliferation than the PCL-LYS-H and was therefore a promising scaffold candidate for use in vascular tissue-engineering | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Polyesters |2 NLM | |
| 650 | 7 | |a Polymers |2 NLM | |
| 650 | 7 | |a polycaprolactone |2 NLM | |
| 650 | 7 | |a 24980-41-4 |2 NLM | |
| 650 | 7 | |a Heparin |2 NLM | |
| 650 | 7 | |a 9005-49-6 |2 NLM | |
| 700 | 1 | |a Feng, Zengguo |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Lianrui |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Tong, Zhu |e verfasserin |4 aut | |
| 700 | 1 | |a Geng, Xue |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Cong |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Hui, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Gu, Yongquan |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of materials science. Materials in medicine |d 1991 |g 31(2020), 8 vom: 05. Aug., Seite 76 |w (DE-627)NLM089783999 |x 1573-4838 |7 nnns |
| 773 | 1 | 8 | |g volume:31 |g year:2020 |g number:8 |g day:05 |g month:08 |g pages:76 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10856-020-06419-0 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 31 |j 2020 |e 8 |b 05 |c 08 |h 76 | ||