Amygdala : Neuroanatomical and Morphophysiological Features in Terms of Neurological and Neurodegenerative Diseases

The amygdala is one of the most discussed structures of the brain. Correlations between its level of activity, size, biochemical organization, and various pathologies are the subject of many studies, and can serve as a marker of existing or future disease. It is hypothesized that the amygdala is not just a structural unit, but includes many other regions in the brain. In this review, we present the updated neuroanatomical and physiological aspects of the amygdala, discussing its involvement in neurodegenerative and neurological diseases. The amygdala plays an important role in the processing of input signals and behavioral synthesis. Lesions in the amygdala have been shown to cause neurological disfunction of ranging severity. Abnormality in the amygdala leads to conditions such as depression, anxiety, autism, and also promotes biochemical and physiological imbalance. The amygdala collects pathological proteins, and this fact can be considered to play a big role in the progression and diagnosis of many degenerative diseases, such as Alzheimer's disease, chronic traumatic encephalopathy, Lewy body diseases, and hippocampal sclerosis. The amygdala has shown to play a crucial role as a central communication system in the brain, therefore understanding its neuroanatomical and physiological features can open a channel for targeted therapy of neurodegenerative diseases.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:10

Enthalten in:

Brain sciences - 10(2020), 8 vom: 31. Juli

Sprache:

Englisch

Beteiligte Personen:

Nikolenko, Vladimir N [VerfasserIn]
Oganesyan, Marine V [VerfasserIn]
Rizaeva, Negoriya A [VerfasserIn]
Kudryashova, Valentina A [VerfasserIn]
Nikitina, Arina T [VerfasserIn]
Pavliv, Maria P [VerfasserIn]
Shchedrina, Marina A [VerfasserIn]
Giller, Dmitry B [VerfasserIn]
Buligin, Kirill V [VerfasserIn]
Sinelnikov, Mikhail Y [VerfasserIn]

Links:

Volltext

Themen:

Amygdala
Journal Article
Limbic system
Neurodegenerative disease
Pathophysiology of neurodegeneration
Review

Anmerkungen:

Date Revised 28.09.2020

published: Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.3390/brainsci10080502

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM313271976