Autologous umbilical cord blood for red cell concentrate transfusion in preterm infants in the era of delayed cord clamping : An uncontrolled clinical trial

© 2020 British Blood Transfusion Society..

OBJECTIVE: To assess the utility of autologous umbilical cord blood (UCB) for red cell concentrate (RCC) transfusion in preterm infants.

METHODS: We recruited preterm infants born at ≤30 weeks' gestation or have an estimated fetal weight <1,200 g. We intended to perform delayed cord clamping (DCC) and to collect UCB following DCC. The quality parameters used included blood culture performed once, and biochemical and haematological parameters assessed weekly.

RESULTS: Of the 46 recruited neonates, DCC could be performed for 1 minute in 11 (23.9%) and for 30-59 seconds in 10 (21.7%) infants. The success rate of UCB collection was significantly lower in infants who underwent DCC for 1 minute (27%) compared to those who underwent DCC for 30-59 seconds (70%) or immediate cord clamping (72%) (p value 0.031). Twenty-five UCBs were stored after eliminating three that had positive culture. UCB had satisfactory quality for transfusion from day 3 (when blood culture report was available) to 14 (after which pH decreased to <6.5). Thirteen infants required 27 RCC transfusions. Autologous UCB could be used for only five (18.5%) transfusions.

CONCLUSION: The success rate of UCB collection after DCC for 1 minute is low. Autologous UCB meets less than one-fifth of transfusion requirements. Hence, autologous UCB transfusion is not a workable option in preterm infants.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:30

Enthalten in:

Transfusion medicine (Oxford, England) - 30(2020), 5 vom: 03. Okt., Seite 391-395

Sprache:

Englisch

Beteiligte Personen:

Abiramalatha, Thangaraj [VerfasserIn]
Radhakrishnan, Krishnamoorthy [VerfasserIn]
Panicker, Vinod Kumar [VerfasserIn]
Ninan, Binu [VerfasserIn]
Godla, Usharani [VerfasserIn]
Chandrasekaran, Ashok [VerfasserIn]
Balakrishnan, Umamaheswari [VerfasserIn]
Amboiram, Prakash [VerfasserIn]

Links:

Volltext

Themen:

Autologous cord blood transfusion
Clinical Trial
Delayed cord clamping
Journal Article
Neonate

Anmerkungen:

Date Completed 29.07.2021

Date Revised 29.07.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1111/tme.12706

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM31319193X