Preterm Twins Born to a Mother with Miliary Tuberculosis : Importance of Early Recognition and Prompt Response in Infection Control to Manage Congenital Tuberculosis Exposure in a Neonatal Intensive Care Unit

Delayed diagnosis of congenital tuberculosis (TB) in the neonatal intensive care unit (NICU) is a serious problem in terms of infection control. Here, we report our preemptive infection control activities implemented after the diagnosis of miliary TB in a mother of preterm twins (index twins, NB1 and NB2) in the NICU. In addition, we reviewed previous case reports of congenital TB exposure in the NICU setting. Immediately after diagnosing miliary TB in the mother, the index twins were isolated before their TB diagnosis and received preemptive anti-TB medication; contact investigations were also conducted. Eventually, NB1 was diagnosed with congenital TB at 29 days of age, and NB2 showed no definite evidence of TB. Through contact investigation, 11 of the 16 exposed infants received isoniazid prophylaxis and no positive tuberculin skin test results were obtained after 3 months. One of the 31 exposed healthcare workers showed new interferon-gamma release assay conversion. Moreover, our case showed a much shorter contagious period compared to that in previous reports (8 versus 17-102 days). This suggests that a high index of suspicion and prompt measures can help prevent congenital TB outbreaks and reduce the burden of infection control activities in the NICU.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:74

Enthalten in:

Japanese journal of infectious diseases - 74(2021), 2 vom: 24. März, Seite 97-101

Sprache:

Englisch

Beteiligte Personen:

Ryu, Byung-Han [VerfasserIn]
Baek, Eun-Hwa [VerfasserIn]
Kim, Da-Hye [VerfasserIn]
Kim, Se-Eun [VerfasserIn]
Kim, Hyun-Ju [VerfasserIn]
Cho, Oh-Hyun [VerfasserIn]
Hong, Sun In [VerfasserIn]
Do, Hyun-Jeong [VerfasserIn]
Park, Chan-Hoo [VerfasserIn]

Links:

Volltext

Themen:

Antitubercular Agents
Case Reports
Congenital tuberculosis
Exposure
Infection control
Isoniazid
Journal Article
NICU
V83O1VOZ8L

Anmerkungen:

Date Completed 08.07.2021

Date Revised 08.07.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.7883/yoken.JJID.2020.183

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM313172919