Preterm Twins Born to a Mother with Miliary Tuberculosis : Importance of Early Recognition and Prompt Response in Infection Control to Manage Congenital Tuberculosis Exposure in a Neonatal Intensive Care Unit
Delayed diagnosis of congenital tuberculosis (TB) in the neonatal intensive care unit (NICU) is a serious problem in terms of infection control. Here, we report our preemptive infection control activities implemented after the diagnosis of miliary TB in a mother of preterm twins (index twins, NB1 and NB2) in the NICU. In addition, we reviewed previous case reports of congenital TB exposure in the NICU setting. Immediately after diagnosing miliary TB in the mother, the index twins were isolated before their TB diagnosis and received preemptive anti-TB medication; contact investigations were also conducted. Eventually, NB1 was diagnosed with congenital TB at 29 days of age, and NB2 showed no definite evidence of TB. Through contact investigation, 11 of the 16 exposed infants received isoniazid prophylaxis and no positive tuberculin skin test results were obtained after 3 months. One of the 31 exposed healthcare workers showed new interferon-gamma release assay conversion. Moreover, our case showed a much shorter contagious period compared to that in previous reports (8 versus 17-102 days). This suggests that a high index of suspicion and prompt measures can help prevent congenital TB outbreaks and reduce the burden of infection control activities in the NICU.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:74 |
---|---|
Enthalten in: |
Japanese journal of infectious diseases - 74(2021), 2 vom: 24. März, Seite 97-101 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Ryu, Byung-Han [VerfasserIn] |
---|
Links: |
---|
Themen: |
Antitubercular Agents |
---|
Anmerkungen: |
Date Completed 08.07.2021 Date Revised 08.07.2021 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.7883/yoken.JJID.2020.183 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM313172919 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM313172919 | ||
003 | DE-627 | ||
005 | 20231225150011.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.7883/yoken.JJID.2020.183 |2 doi | |
028 | 5 | 2 | |a pubmed24n1043.xml |
035 | |a (DE-627)NLM313172919 | ||
035 | |a (NLM)32741929 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Ryu, Byung-Han |e verfasserin |4 aut | |
245 | 1 | 0 | |a Preterm Twins Born to a Mother with Miliary Tuberculosis |b Importance of Early Recognition and Prompt Response in Infection Control to Manage Congenital Tuberculosis Exposure in a Neonatal Intensive Care Unit |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 08.07.2021 | ||
500 | |a Date Revised 08.07.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Delayed diagnosis of congenital tuberculosis (TB) in the neonatal intensive care unit (NICU) is a serious problem in terms of infection control. Here, we report our preemptive infection control activities implemented after the diagnosis of miliary TB in a mother of preterm twins (index twins, NB1 and NB2) in the NICU. In addition, we reviewed previous case reports of congenital TB exposure in the NICU setting. Immediately after diagnosing miliary TB in the mother, the index twins were isolated before their TB diagnosis and received preemptive anti-TB medication; contact investigations were also conducted. Eventually, NB1 was diagnosed with congenital TB at 29 days of age, and NB2 showed no definite evidence of TB. Through contact investigation, 11 of the 16 exposed infants received isoniazid prophylaxis and no positive tuberculin skin test results were obtained after 3 months. One of the 31 exposed healthcare workers showed new interferon-gamma release assay conversion. Moreover, our case showed a much shorter contagious period compared to that in previous reports (8 versus 17-102 days). This suggests that a high index of suspicion and prompt measures can help prevent congenital TB outbreaks and reduce the burden of infection control activities in the NICU | ||
650 | 4 | |a Case Reports | |
650 | 4 | |a Journal Article | |
650 | 4 | |a NICU | |
650 | 4 | |a congenital tuberculosis | |
650 | 4 | |a exposure | |
650 | 4 | |a infection control | |
650 | 7 | |a Antitubercular Agents |2 NLM | |
650 | 7 | |a Isoniazid |2 NLM | |
650 | 7 | |a V83O1VOZ8L |2 NLM | |
700 | 1 | |a Baek, Eun-Hwa |e verfasserin |4 aut | |
700 | 1 | |a Kim, Da-Hye |e verfasserin |4 aut | |
700 | 1 | |a Kim, Se-Eun |e verfasserin |4 aut | |
700 | 1 | |a Kim, Hyun-Ju |e verfasserin |4 aut | |
700 | 1 | |a Cho, Oh-Hyun |e verfasserin |4 aut | |
700 | 1 | |a Hong, Sun In |e verfasserin |4 aut | |
700 | 1 | |a Do, Hyun-Jeong |e verfasserin |4 aut | |
700 | 1 | |a Park, Chan-Hoo |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Japanese journal of infectious diseases |d 1999 |g 74(2021), 2 vom: 24. März, Seite 97-101 |w (DE-627)NLM104387572 |x 1884-2836 |7 nnns |
773 | 1 | 8 | |g volume:74 |g year:2021 |g number:2 |g day:24 |g month:03 |g pages:97-101 |
856 | 4 | 0 | |u http://dx.doi.org/10.7883/yoken.JJID.2020.183 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 74 |j 2021 |e 2 |b 24 |c 03 |h 97-101 |