The Development of Pathological Dependence after Intermittent Use of Sodium Glutamate, but Not Sucrose or Sodium Chloride Solutions
The possibility of development of dependence was studied during the intermittent consumption of sucrose, sodium chloride, and sodium glutamate solutions. Rats were allowed to choose and consume solutions of sucrose, sodium chloride, and sodium glutamate for 28 days. On days 29-31 of the experiment, the animals were deprived of the preferred solutions. On days 32-33, the solutions of sucrose, sodium chloride, and sodium glutamate, but not water were provided again. The consumption of sucrose and sodium chloride solutions did not increase, but consumption of 0.5 and 1% sodium glutamate solutions increased after 3-days withdrawal. The consumption of 2% solution of sodium glutamate was the same before and after withdrawal. The observed effects of sodium glutamate deprivation probably indicate the development of pathological glutamate dependence.
| Errataetall: |
CommentIn: Bull Exp Biol Med. 2021 Sep;171(5):681-682. - PMID 34618263 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:169 |
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| Enthalten in: |
Bulletin of experimental biology and medicine - 169(2020), 3 vom: 31. Juli, Seite 324-327 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sudakov, S K [VerfasserIn] |
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| Links: |
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| Themen: |
451W47IQ8X |
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| Anmerkungen: |
Date Completed 07.06.2021 Date Revised 02.02.2022 published: Print-Electronic CommentIn: Bull Exp Biol Med. 2021 Sep;171(5):681-682. - PMID 34618263 Citation Status MEDLINE |
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| doi: |
10.1007/s10517-020-04879-6 |
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| PPN (Katalog-ID): |
NLM313131953 |
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| 520 | |a The possibility of development of dependence was studied during the intermittent consumption of sucrose, sodium chloride, and sodium glutamate solutions. Rats were allowed to choose and consume solutions of sucrose, sodium chloride, and sodium glutamate for 28 days. On days 29-31 of the experiment, the animals were deprived of the preferred solutions. On days 32-33, the solutions of sucrose, sodium chloride, and sodium glutamate, but not water were provided again. The consumption of sucrose and sodium chloride solutions did not increase, but consumption of 0.5 and 1% sodium glutamate solutions increased after 3-days withdrawal. The consumption of 2% solution of sodium glutamate was the same before and after withdrawal. The observed effects of sodium glutamate deprivation probably indicate the development of pathological glutamate dependence | ||
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