Evolutionarily Conserved Roles for Apontic in Induction and Subsequent Decline of Cyclin E Expression
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved..
Cyclin E is a key factor for S phase entry, and deregulation of Cyclin E results in developmental defects and tumors. Therefore, proper cycling of Cyclin E is crucial for normal growth. Here we found that transcription factors Apontic (Apt) and E2f1 cooperate to induce cyclin E in Drosophila. Functional binding motifs of Apt and E2f1 are clustered in the first intron of Drosophila cyclin E and directly contribute to the cyclin E transcription. Knockout of apt and e2f1 together abolished Cyclin E expression. Furthermore, Apt up-regulates Retinoblastoma family protein 1 (Rbf1) for proper chromatin compaction, which is known to repress cyclin E. Notably, Apt-dependent up-regulation of Cyclin E and Rbf1 is evolutionarily conserved in mammalian cells. Our findings reveal a unique mechanism underlying the induction and subsequent decline of Cyclin E expression.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
iScience - 23(2020), 8 vom: 21. Aug., Seite 101369 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Xian-Feng [VerfasserIn] |
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| Links: |
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| Themen: |
Biological Sciences |
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| Anmerkungen: |
Date Revised 10.01.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.isci.2020.101369 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Cyclin E is a key factor for S phase entry, and deregulation of Cyclin E results in developmental defects and tumors. Therefore, proper cycling of Cyclin E is crucial for normal growth. Here we found that transcription factors Apontic (Apt) and E2f1 cooperate to induce cyclin E in Drosophila. Functional binding motifs of Apt and E2f1 are clustered in the first intron of Drosophila cyclin E and directly contribute to the cyclin E transcription. Knockout of apt and e2f1 together abolished Cyclin E expression. Furthermore, Apt up-regulates Retinoblastoma family protein 1 (Rbf1) for proper chromatin compaction, which is known to repress cyclin E. Notably, Apt-dependent up-regulation of Cyclin E and Rbf1 is evolutionarily conserved in mammalian cells. Our findings reveal a unique mechanism underlying the induction and subsequent decline of Cyclin E expression | ||
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| 700 | 1 | |a Ma, Zhi-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Hao-Ran |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Zi-Zhang |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Emiko |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Qing-Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Hirose, Susumu |e verfasserin |4 aut | |
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