Functions of Endothelial Cilia in the Regulation of Vascular Barriers

Copyright © 2020 Ma and Zhou..

The vascular barrier between blood and tissues is a highly selective structure that is essential to maintain tissue homeostasis. Defects in the vascular barrier lead to a variety of cardiovascular diseases. The maintenance of vascular barriers is largely dependent on endothelial cells, but the precise mechanisms remain elusive. Recent studies reveal that primary cilia, microtubule-based structures that protrude from the surface of endothelial cells, play a critical role in the regulation of vascular barriers. Herein, we discuss recent advances on ciliary functions in the vascular barrier and suggest that ciliary signaling pathways might be targeted to modulate the vascular barrier.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:8

Enthalten in:

Frontiers in cell and developmental biology - 8(2020) vom: 17., Seite 626

Sprache:

Englisch

Beteiligte Personen:

Ma, Nan [VerfasserIn]
Zhou, Jun [VerfasserIn]

Links:

Volltext

Themen:

Disease
Endothelial cell
Journal Article
Primary cilium
Review
Signaling pathway
Vascular barrier

Anmerkungen:

Date Revised 28.09.2020

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.3389/fcell.2020.00626

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM313094179